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dc.contributor.authorBatzloff, Michael R.en_US
dc.contributor.authorHartas, Jonen_US
dc.contributor.authorZeng, Weiguangen_US
dc.contributor.authorJackson, David C.en_US
dc.contributor.authorGood, Michael F.en_US
dc.date.accessioned2017-05-03T14:54:01Z
dc.date.available2017-05-03T14:54:01Z
dc.date.issued2006en_US
dc.date.modified2014-05-22T22:17:09Z
dc.identifier.issn00221899en_US
dc.identifier.doi10.1086/505146en_US
dc.identifier.urihttp://hdl.handle.net/10072/59236
dc.description.abstractInfection with group A streptococcus (GAS) may result in a number of human diseases, including potentially life-threatening postinfectious sequelae. In the present study, J14, a conformationally constrained conserved minimal peptide from the M protein, was incorporated into a lipopeptide construct to which a universal T cell epitope and a self-adjuvanting lipid moiety, Pam2Cys, were also attached. We demonstrate that this lipopeptide construct, when administered intranasally (inl) without additional adjuvants, protects outbred mice from lethal respiratory GAS challenge. In addition, the lipopeptide was capable of inducing J14-specific mucosal immunoglobulin A, which coincided with reduced throat colonization after respiratory GAS challenge. These preclinical experiments show that this lipopeptide could form the basis of an antidisease and transmission-blocking inl GAS vaccineen_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.publisherOxford University Pressen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom325en_US
dc.relation.ispartofpageto330en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalJournal of Infectious Diseasesen_US
dc.relation.ispartofvolume194en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchMedical Microbiology not elsewhere classifieden_US
dc.subject.fieldofresearchcode110899en_US
dc.titleIntranasal Vaccination with a Lipopeptide Containing a Conformationally Constrained Conserved Minimal Peptide, a Universal T Cell Epitope, and a Self-Adjuvanting Lipid Protects Mice from Group A Streptococcus Challenge and Reduces Throat Colonizationen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.hasfulltextNo Full Text
gro.griffith.authorGood, Michael F.


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