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  • Antibacterial Activity of Selected Australian Syzygium species

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    Author(s)
    Chikowe, Getmore
    Mpala, Lindiwe
    Cock, Ian
    Griffith University Author(s)
    Cock, Ian E.
    Mpala, Lindiwe N.
    Chikowe, Getmore R.
    Year published
    2013
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    Abstract
    Introduction: Many species of Syzygium are known to have antiseptic activity. Australian Syzygium species had roles as traditional bush medicines for Australian Aborigines although their antiseptic potential has not been rigorously studied. Methods: Methanol extracts of leaves from Syzygium forte, Syzygium francissi, Syzygium moorei, Syzygium puberulum and Syzygium wilsonii were tested for antimicrobial activity by disc diffusion assay. Antibacterial strength was measured by MIC determination. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: S. forte, S. francissi, S. moorei, S. puberulum and ...
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    Introduction: Many species of Syzygium are known to have antiseptic activity. Australian Syzygium species had roles as traditional bush medicines for Australian Aborigines although their antiseptic potential has not been rigorously studied. Methods: Methanol extracts of leaves from Syzygium forte, Syzygium francissi, Syzygium moorei, Syzygium puberulum and Syzygium wilsonii were tested for antimicrobial activity by disc diffusion assay. Antibacterial strength was measured by MIC determination. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: S. forte, S. francissi, S. moorei, S. puberulum and S. wilsonii leaf methanolic extracts inhibited the growth of 5 (36%), 3 (21%), 3 (21%), 5 (36%) and 2 (14%) of the 14 bacteria tested respectively. Both Gram-positive and Gram-negative bacterial growth was inhibited by the Syzygium extracts, although Gram-positive bacteria appeared slightly more susceptible. With the exception of S. forte, all Syzygium leaf extracts tested also displayed low toxicity (LC50 > 1000 姯ml) in the Artemia fransiscana bioassay. S. forte had a 48 h LC50 of 392.4 ᠳ3.0 姯ml, making it slightly more toxic than Mevinphos (495.0 ᠳ5.1 姯ml) and approximately 28 fold less toxic than potassium dichromate (14.0 ᠲ.4 姯ml) at 48 h. Conclusions: The antibacterial activity and low toxicity of the Syzygium spp. validate their medicinal usage by Australian Aborigines and indicate their potential as antibacterial medicinal agents.
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    Journal Title
    Pharmacognosy Communications
    Volume
    3
    Issue
    4
    Publisher URI
    http://www.phcogcommn.org/content/past-issues
    Copyright Statement
    © 2013 Phcog.net. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Plant Biology not elsewhere classified
    Plant Biology
    Pharmacology and Pharmaceutical Sciences
    Publication URI
    http://hdl.handle.net/10072/59246
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