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  • Microsatellite alterations in squamous cell carcinomas of the head and neck- clustering of loss of heterozygosity in a distinct subset.

    Author(s)
    Ng, IOL
    Xiao, L
    Lam, KY
    Yuen, PW
    Ng, M
    Griffith University Author(s)
    Lam, Alfred K.
    Year published
    2000
    Metadata
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    Abstract
    Loss of heterozygosity (LOH) and microsatellite instability (MSI) have been recognized as important events in the carcinogenesis of many cancers, including squamous cell carcinoma of head and neck (SCCHN). However, microsatellite alterations have not been documented in SCCHN from Chinese patients. We investigated the frequency and clinical significance of LOH and MSI in 30 SCCHN from Hong Kong Chinese using polymerase chain reaction on 17 microsatellite markers on chromosomes 3p, 4q, 7q, 9p, 17p and 18q. LOH was present in nine tumours (30%) and MSI in four (13%). The incidence of LOH (7/13; 53.8%) in hypopharyngeal–laryngeal ...
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    Loss of heterozygosity (LOH) and microsatellite instability (MSI) have been recognized as important events in the carcinogenesis of many cancers, including squamous cell carcinoma of head and neck (SCCHN). However, microsatellite alterations have not been documented in SCCHN from Chinese patients. We investigated the frequency and clinical significance of LOH and MSI in 30 SCCHN from Hong Kong Chinese using polymerase chain reaction on 17 microsatellite markers on chromosomes 3p, 4q, 7q, 9p, 17p and 18q. LOH was present in nine tumours (30%) and MSI in four (13%). The incidence of LOH (7/13; 53.8%) in hypopharyngeal–laryngeal cancers was significantly higher than that (2/17; 11.8%) in the oral cancers (P=0.020). LOH was more often detected at the loci on chromosomes 7 and 9. Patients with tumours having LOH had slightly poorer outcome compared with those without, although the differences did not reach statistical significance. Our data show that the incidence of microsatellite alterations in SCCHN from Hong Kong Chinese is low. However, LOH may be one of the genetic mechanisms in the carcinogenesis of a subset of SCCHN (hypopharyngeal–laryngeal cancers).
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    Journal Title
    Oral Oncology
    Volume
    36
    DOI
    https://doi.org/10.1016/S1368-8375(00)00040-3
    Subject
    Oncology and Carcinogenesis
    Dentistry
    Public Health and Health Services
    Publication URI
    http://hdl.handle.net/10072/59262
    Collection
    • Journal articles

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