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  • Pectentoxins - An issue for public health: A review of their comparative toxicology and metabolism.

    Author(s)
    Burgess, Vanessa
    Shaw, Glendon Reginald
    Griffith University Author(s)
    Shaw, Glendon R.
    Year published
    2001
    Metadata
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    Abstract
    Pectenotoxins (PTXs) are a group of toxins associated with diarrhetic shellfish poisoning (DSP) and isolated from DSP toxin-producing dinoflagellate algae. Consumption of shellfish contaminated with PTXs has been associated with incidences of severe diarrhetic illness resulting in hospitalisation. Concern has been raised for public health following the discovery that these toxins are not only hepatotoxic and can cause diarrhetic effects in mammals, but that they are potently cytotoxic to human cancer cell lines and have been found to be tumour promoters in animals. With advances in knowledge and technology, more PTXs are ...
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    Pectenotoxins (PTXs) are a group of toxins associated with diarrhetic shellfish poisoning (DSP) and isolated from DSP toxin-producing dinoflagellate algae. Consumption of shellfish contaminated with PTXs has been associated with incidences of severe diarrhetic illness resulting in hospitalisation. Concern has been raised for public health following the discovery that these toxins are not only hepatotoxic and can cause diarrhetic effects in mammals, but that they are potently cytotoxic to human cancer cell lines and have been found to be tumour promoters in animals. With advances in knowledge and technology, more PTXs are being identified, but little is known of their toxicology and the potential impact these toxins may have on public health in the long term. Without such information, adequate health-risk assessments for the consumption of shellfish contaminated with PTXs cannot be performed. This review gives a brief introduction to diarrhetic shellfish toxins, details the known toxicology and metabolism of PTXs in animals, and discusses known incidences of PTX poisoning in humans
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    Journal Title
    Environment International
    Volume
    27
    Issue
    4
    DOI
    https://doi.org/10.1016/S0160-4120(01)00058-7
    Subject
    PRE2009-Environmental and Occupational Health and Safety
    Publication URI
    http://hdl.handle.net/10072/59301
    Collection
    • Journal articles

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