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dc.contributor.authorM. Moyle, Peter
dc.contributor.authorHari, Yashmeeta
dc.contributor.authorHuang, Ning
dc.contributor.authorOlive, Colleen
dc.contributor.authorF. Good, Michael
dc.contributor.authorToth, Istvan
dc.date.accessioned2017-05-03T14:54:41Z
dc.date.available2017-05-03T14:54:41Z
dc.date.issued2007
dc.date.modified2014-05-26T00:58:42Z
dc.identifier.issn00404039
dc.identifier.doi10.1016/j.tetlet.2007.05.129
dc.identifier.urihttp://hdl.handle.net/10072/59326
dc.description.abstractThe synthesis of lipid core peptide (LCP) vaccines using stepwise solid-phase peptide synthesis commonly results in products which are difficult to purify to homogeneity. A new technique for synthesizing highly-pure, mono-epitopic, multi-valent LCP-systems using native chemical ligation is presented. Various conditions were assessed for ligating four copies of a thioester-modified 88/30 serotype group A streptococcal peptide antigen onto an LCP-system featuring four cysteine residues. Overall, the vaccine was synthesized in high purity (>99%), and high yield (90%) when the ligation reaction was performed in the presence of 1% sodium dodecyl sulfate and at elevated temperatures (37 é.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherPergamon
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom4965
dc.relation.ispartofpageto4967
dc.relation.ispartofissue29
dc.relation.ispartofjournalTetrahedron Letters
dc.relation.ispartofvolume48
dc.rights.retentionY
dc.subject.fieldofresearchOrganic Chemistry not elsewhere classified
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry
dc.subject.fieldofresearchOrganic Chemistry
dc.subject.fieldofresearchcode030599
dc.subject.fieldofresearchcode0304
dc.subject.fieldofresearchcode0305
dc.titleA technique for the synthesis of highly-pure, mono-epitopic, multi-valent lipid core peptide vaccines
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorGood, Michael F.


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