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  • Short latency afferent inhibition: A biomarker for mild cognitive impairment in Parkinson's disease?

    Author(s)
    Yarnall, AJ
    Rochester, L
    Baker, MR
    David, R
    Khoo, TK
    Duncan, GW
    Galna, B
    Burn, DJ
    Griffith University Author(s)
    Khoo, Tien Kheng
    Year published
    2013
    Metadata
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    Abstract
    Background Mild cognitive impairment in Parkinson's disease (PD) is common and predicts those at risk of dementia. Cholinergic dysfunction may contribute to its pathophysiology and can be assessed using short latency afferent inhibition. Methods Twenty-two patients with PD (11 cognitively normal; 11 with mild cognitive impairment) and 22 controls participated. Short latency afferent inhibition was measured by conditioning motor evoked potentials, which were elicited by transcranial magnetic stimulation of the motor cortex with electrical stimuli delivered to the contralateral median nerve at varying interstimulus ...
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    Background Mild cognitive impairment in Parkinson's disease (PD) is common and predicts those at risk of dementia. Cholinergic dysfunction may contribute to its pathophysiology and can be assessed using short latency afferent inhibition. Methods Twenty-two patients with PD (11 cognitively normal; 11 with mild cognitive impairment) and 22 controls participated. Short latency afferent inhibition was measured by conditioning motor evoked potentials, which were elicited by transcranial magnetic stimulation of the motor cortex with electrical stimuli delivered to the contralateral median nerve at varying interstimulus intervals. Results There was no significant difference between cognitively normal PD and controls for short latency afferent inhibition (62.8±30.3% vs. 55.7±21.7%; P=0.447). The PD-mild cognitive impairment group had significantly less inhibition (88.4±25.8%) than both cognitively normal PD (P=0.021) and controls (P=0.01). Conclusions Cholinergic dysfunction occurs early in those with PD-mild cognitive impairment. Short latency afferent inhibition may be a useful biomarker of increased risk of dementia in PD patients. © 2013 Movement Disorder Society
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    Journal Title
    Movement Disorders
    Volume
    28
    Issue
    9
    DOI
    https://doi.org/10.1002/mds.25360
    Copyright Statement
    Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
    Subject
    Neurosciences not elsewhere classified
    Clinical Sciences
    Human Movement and Sports Sciences
    Neurosciences
    Publication URI
    http://hdl.handle.net/10072/59663
    Collection
    • Journal articles

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