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dc.contributor.authorYarnall, AJ
dc.contributor.authorRochester, L
dc.contributor.authorBaker, MR
dc.contributor.authorDavid, R
dc.contributor.authorKhoo, TK
dc.contributor.authorDuncan, GW
dc.contributor.authorGalna, B
dc.contributor.authorBurn, DJ
dc.date.accessioned2013-12-17
dc.date.accessioned2014-05-30T03:20:00Z
dc.date.accessioned2017-03-01T23:58:09Z
dc.date.available2017-03-01T23:58:09Z
dc.date.issued2013
dc.date.modified2014-05-30T03:20:00Z
dc.identifier.issn0885-3185
dc.identifier.doi10.1002/mds.25360
dc.identifier.urihttp://hdl.handle.net/10072/59663
dc.description.abstractBackground Mild cognitive impairment in Parkinson's disease (PD) is common and predicts those at risk of dementia. Cholinergic dysfunction may contribute to its pathophysiology and can be assessed using short latency afferent inhibition. Methods Twenty-two patients with PD (11 cognitively normal; 11 with mild cognitive impairment) and 22 controls participated. Short latency afferent inhibition was measured by conditioning motor evoked potentials, which were elicited by transcranial magnetic stimulation of the motor cortex with electrical stimuli delivered to the contralateral median nerve at varying interstimulus intervals. Results There was no significant difference between cognitively normal PD and controls for short latency afferent inhibition (62.8±30.3% vs. 55.7±21.7%; P=0.447). The PD-mild cognitive impairment group had significantly less inhibition (88.4±25.8%) than both cognitively normal PD (P=0.021) and controls (P=0.01). Conclusions Cholinergic dysfunction occurs early in those with PD-mild cognitive impairment. Short latency afferent inhibition may be a useful biomarker of increased risk of dementia in PD patients. © 2013 Movement Disorder Society
dc.description.peerreviewedNo
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley & Sons, Inc.
dc.publisher.placeUnited States of America
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1285
dc.relation.ispartofpageto1288
dc.relation.ispartofissue9
dc.relation.ispartofjournalMovement Disorders
dc.relation.ispartofvolume28
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchNeurosciences not elsewhere classified
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4207
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode320999
dc.titleShort latency afferent inhibition: A biomarker for mild cognitive impairment in Parkinson's disease?
dc.typeJournal article
dc.type.descriptionC2 - Articles (Other)
dc.type.codec2x
gro.facultyGriffith Health Faculty
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
gro.hasfulltextNo Full Text
gro.griffith.authorKhoo, Tien Kheng


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