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  • Dual antiplatelet therapy -- management in general practice.

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    91880_1.pdf (95.65Kb)
    Author(s)
    Jayasinghe, Rohan
    Markham, Ryan
    Adsett, Geoffrey
    Griffith University Author(s)
    Jayasinghe, Satyajit R.
    Year published
    2013
    Metadata
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    Abstract
    Background Prasugrel and ticagrelor are two new antiplatelet agents being used in the management of acute coronary syndromes. The number of patients in the community managed on these medications is growing, and thus, it is essential that general practitioners have a good understanding of these agents and their evidence-based applications. Objective The pharmacokinetic and pharmacodynamic properties of common and new antiplatelet agents will be reviewed, along with the evidence supporting their use. Safety and side effect profiles will be discussed, and some common general practice case scenarios presented. Discussion Aspirin ...
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    Background Prasugrel and ticagrelor are two new antiplatelet agents being used in the management of acute coronary syndromes. The number of patients in the community managed on these medications is growing, and thus, it is essential that general practitioners have a good understanding of these agents and their evidence-based applications. Objective The pharmacokinetic and pharmacodynamic properties of common and new antiplatelet agents will be reviewed, along with the evidence supporting their use. Safety and side effect profiles will be discussed, and some common general practice case scenarios presented. Discussion Aspirin is still the mainstay of therapy in patients with acute coronary syndromes. The addition of clopidogrel, prasugrel or ticagrelor can reduce morbidity and mortality in selected patients. Patient factors including bleeding risk, renal function and time since coronary stent insertion must be reviewed before these agents are initiated and before making any changes to the medication regimen.
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    Journal Title
    Australian Family Physician
    Volume
    42
    Issue
    10
    Publisher URI
    http://www.racgp.org.au/afp/2013/october/dual-antiplatelet-therapy/
    Copyright Statement
    © 2013 Australian Family Physician. Reproduced with permission. Permission to reproduce must be sought from the publisher, The Royal Australian College of General Practitioners.
    Subject
    Medical and Health Sciences not elsewhere classified
    Clinical Sciences
    Public Health and Health Services
    Publication URI
    http://hdl.handle.net/10072/59746
    Collection
    • Journal articles

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