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dc.contributor.authorBeran, Roy G
dc.contributor.authorHegazi, Yaser
dc.contributor.authorSchwartz, Raymond S
dc.contributor.authorCordato, Dennis J
dc.date.accessioned2014-02-12
dc.date.accessioned2014-06-03T02:55:15Z
dc.date.accessioned2017-03-02T00:21:03Z
dc.date.available2017-03-02T00:21:03Z
dc.date.issued2013
dc.date.modified2014-06-03T02:55:15Z
dc.identifier.issn2211-0348
dc.identifier.doi10.1016/j.msard.2012.11.001
dc.identifier.urihttp://hdl.handle.net/10072/59801
dc.description.abstractBackground Multiple sclerosis (MS) management is changing, revolutionized by oral agents. Immune Reconstitution Inflammatory Syndrome (IRIS) describes exaggerated response to both exogenous (infective) and endogenous (non-infective) antigens. Methods This paper reports two cases of MS “rebound” following withdrawal of oral treatments. Results Two patients, with suboptimal response to interferons, trialled oral MS treatment (fingolimod and BG12) with excellent response. Upon cessation both experienced MS “rebound” which responded to steroids. Conclusions “Rebound” may occur following withdrawal of oral MS therapies. Patients should be advised accordingly and possibly started on alternative treatment before the immunomodulating effect of therapy has subsided.
dc.description.peerreviewedNo
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom252
dc.relation.ispartofpageto255
dc.relation.ispartofissue3
dc.relation.ispartofjournalMultiple Sclerosis and Related Disorders
dc.relation.ispartofvolume2
dc.rights.retentionY
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode3209
dc.titleRebound exacerbation multiple sclerosis following cessation of oral treatment.
dc.typeJournal article
dc.type.descriptionC2 - Articles (Other)
dc.type.codec2
gro.facultyGriffith Health Faculty
gro.hasfulltextNo Full Text
gro.griffith.authorBeran, Roy G.


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