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  • Commentary on "Possible induction of acute disseminated encephalomyelitis (ADEM)-like demyelinating illness by intrathecal mesenchymal stem cell injection".

    Author(s)
    Butzkueven, Helmut
    Griffith University Author(s)
    Butzkueven, Helmut
    Year published
    2013
    Metadata
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    Abstract
    The case report that is the subject of this Commentary describes a 27-year-old woman, who, 3 months after a devastating low cervical myelitis, underwent intrathecal mesenchymal stem cell (MSC) infusions. Six hours after the third infusion, she became unconscious, febrile and cerebral MRI showed acute bitemporal and left cerebellar lesions, consistent with an acute disseminated encephalomyelitis. It is likely that this is the first reported patient with neuroinflammatory exacerbation after MSC therapy. This case suggests that, in addition to their malignant potential, autologous MSC expanded in vitro can exhibit immune-activating ...
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    The case report that is the subject of this Commentary describes a 27-year-old woman, who, 3 months after a devastating low cervical myelitis, underwent intrathecal mesenchymal stem cell (MSC) infusions. Six hours after the third infusion, she became unconscious, febrile and cerebral MRI showed acute bitemporal and left cerebellar lesions, consistent with an acute disseminated encephalomyelitis. It is likely that this is the first reported patient with neuroinflammatory exacerbation after MSC therapy. This case suggests that, in addition to their malignant potential, autologous MSC expanded in vitro can exhibit immune-activating properties leading to autoimmune exacerbation.
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    Journal Title
    Journal of Clinical Neuroscience
    Volume
    20
    Issue
    2
    DOI
    https://doi.org/10.1016/j.jocn.2012.06.003
    Subject
    Medical and Health Sciences not elsewhere classified
    Clinical Sciences
    Neurosciences
    Publication URI
    http://hdl.handle.net/10072/59802
    Collection
    • Journal articles

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