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dc.contributor.authorSharma, D
dc.contributor.authorDouglas, J
dc.contributor.authorCoulter, C
dc.contributor.authorWeinrauch, P
dc.contributor.authorCrawford, R
dc.date.accessioned2017-05-03T16:17:22Z
dc.date.available2017-05-03T16:17:22Z
dc.date.issued2008
dc.date.modified2014-06-11T01:14:10Z
dc.identifier.issn1022-5536
dc.identifier.urihttp://hdl.handle.net/10072/59873
dc.description.abstractPURPOSE: To classify the spectrum and antibiotic susceptibility of bacteria isolated from infected hip and knee arthroplasty specimens, and to recommend appropriate empiric peri-operative antibiotics. METHODS: From January 1999 to August 2006, specimens from revision hip and knee arthroplasties (with or without suspected infection) were routinely collected for identifying possible organisms and their susceptibility patterns. During the period, 147 patients had positive specimens yielding 248 micro-organisms (from 195 tissue specimens, 43 fluid specimens, and 10 swabs). 140 isolates were from hips and 108 from knees. RESULTS: Most isolates were Gram-positive; their distribution was similar in hip and knee specimens. Of the 248 micro-organisms isolated, Staphylococcus was the most common genus encountered (131, 53%), followed by Gram-negative isolates (24%). 88% of Gram-negative organisms were detected within 48 hours of inoculation and 94% of Gram-positive organisms within 96 hours. Overall, 46% of isolates were susceptible to cephalothin. Only 35% of coagulase-negative staphylococci were sensitive to cephalothin. No Gram-positive vancomycin resistance was encountered. CONCLUSION: Empiric prophylactic antibiotics for revision hip and knee arthroplasties should include vancomycin to cover Gram-positive organisms and gentamicin for most Gram-negative bacteria.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent257640 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherHong Kong Academy of Medicine Press
dc.publisher.placeHong Kong
dc.publisher.urihttp://www.josonline.org/index.php/JOS/article/view/458
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom339
dc.relation.ispartofpageto342
dc.relation.ispartofissue3
dc.relation.ispartofjournalJournal of Orthopaedic Surgery
dc.relation.ispartofvolume16
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.titleMicrobiology of infected arthroplasty: implications for empiric peri-operative antibiotics
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2008 Journal of Orthopaedic Surgery. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2008
gro.hasfulltextFull Text
gro.griffith.authorWeinrauch, Patrick C.


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