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  • Targeting CD83 for the treatment of graft-versus-host disease

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    Author(s)
    Wang, Xiongfei
    Wei, Ming Q
    Liu, Xiaosong
    Griffith University Author(s)
    Wei, Ming Q.
    Year published
    2013
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    Abstract
    Graft-versus-host disease (GVHD) is a common and often fatal complication of bone marrow transplantation. Antigen-presenting cells from donor and recipient play a critical role in the initiation and maintenance of GVHD. CD83, which is expressed in activated lymphocytes and dendritic cells, is regarded as a marker of mature dendritic cells. Targeting CD83 using soluble CD83 molecules or antibodies has been demonstrated to have therapeutic effects against GVHD in preclinical models. Understanding the biological function of CD83 and the underlying mechanisms through which targeting CD83 attenuates GVHD is likely to greatly ...
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    Graft-versus-host disease (GVHD) is a common and often fatal complication of bone marrow transplantation. Antigen-presenting cells from donor and recipient play a critical role in the initiation and maintenance of GVHD. CD83, which is expressed in activated lymphocytes and dendritic cells, is regarded as a marker of mature dendritic cells. Targeting CD83 using soluble CD83 molecules or antibodies has been demonstrated to have therapeutic effects against GVHD in preclinical models. Understanding the biological function of CD83 and the underlying mechanisms through which targeting CD83 attenuates GVHD is likely to greatly improve current treatments and provide new methods for the treatment of GVHD.
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    Journal Title
    Experimental and Therapeutic Medicine
    Volume
    5
    Issue
    6
    DOI
    https://doi.org/10.3892/etm.2013.1033
    Copyright Statement
    © 2013 Spandidos Publications. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Traditional, complementary and integrative medicine
    Nutrition and dietetics
    Molecular targets
    Publication URI
    http://hdl.handle.net/10072/60029
    Collection
    • Journal articles

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