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dc.contributor.authorWainwright, Claire E
dc.contributor.authorGrimwood, Keith
dc.contributor.authorCarlin, John B
dc.contributor.authorVidmar, Suzanna
dc.contributor.authorCooper, Peter J
dc.contributor.authorFrancis, Paul W
dc.contributor.authorByrnes, Catherine A
dc.contributor.authorWhitehead, Bruce F
dc.contributor.authorMartin, A James
dc.contributor.authorRobertson, Ian F
dc.contributor.authorCooper, David M
dc.contributor.authorDakin, Carolyn J
dc.contributor.authorMasters, Ian B
dc.contributor.authorMassie, R John
dc.contributor.authorRobinson, Philip J
dc.contributor.authorRanganathan, Sarath
dc.contributor.authorArmstrong, David S
dc.contributor.authorPatterson, Lyndall K
dc.contributor.authorRobertson, Colin F
dc.date.accessioned2017-05-03T13:13:30Z
dc.date.available2017-05-03T13:13:30Z
dc.date.issued2008
dc.date.modified2014-06-12T23:40:50Z
dc.identifier.issn8755-6863
dc.identifier.doi10.1002/ppul.20885
dc.identifier.urihttp://hdl.handle.net/10072/60072
dc.description.abstractObjective: Our aim was to determine the safety of BAL in young children <6 years with CF. Methods: As part of a multi-center study of BAL-directed therapy, children with CF?<?6 years had one or more BALs between September 1999 and December 2005. Adverse events were recorded intraoperatively and for 24 hr thereafter. Clinical characteristics before BAL, findings at bronchoscopy and BAL results were assessed as risk factors for adverse events. Results: 333 BALs were conducted in 107 (56 males) children, median age 23.5 (range 1.6-67.5) months, including 170 (51%) for pulmonary exacerbation. 29 BALs (8.7%) were followed by fever =38.5àand 10 (3%) had clinically significant episodes (five intraoperative hemoglobin desaturations to <90% requiring intervention, one tachyarrhythmia, two needing post-operative supplemental oxygen, one hospitalization for stridor). Two contaminated bronchoscopes were detected. 180 minor adverse events were recorded in 174 (52%) BAL procedures (137 altered cough, 41 fever <38.5é. Low percentage BAL return (P?=?0.002) and focal bronchitis (P?=?0.02) were associated with clinically significant deterioration. Multivariable analysis identified Streptococcus pneumoniae (OR 22.3; 95% confidence interval (CI); 6.9,72), Pseudomonas aeruginosa (OR 2.4; 95% CI 1.0, 5.8), respiratory signs (OR 5.0; 95% CI 1.7, 14.6) and focal bronchitis (OR 5.9; 95% CI 1.2, 29.8) as independent risk factors for post-bronchoscopy fever =38.5î Conclusions: Adverse events are common with BAL in young CF children, but are usually transient and well tolerated. Parents should be counseled that signs of a pre-existing lower respiratory infection are associated with increased risk of post-BAL fever.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley & Sons, Inc.
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom965
dc.relation.ispartofpageto972
dc.relation.ispartofjournalPediatric Pulmonology
dc.relation.ispartofvolume43
dc.rights.retentionY
dc.subject.fieldofresearchReproductive medicine not elsewhere classified
dc.subject.fieldofresearchcode321599
dc.titleSafety of Bronchoalveolar Lavage in Young Children With Cystic Fibrosis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorGrimwood, Keith


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