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dc.contributor.authorAl-Dasooqi, Noor
dc.contributor.authorT. Sonis, Stephen
dc.contributor.authorBowen, Joanne M.
dc.contributor.authorBateman, Emma
dc.contributor.authorBlijlevens, Nicole
dc.contributor.authorJ. Gibson, Rachel
dc.contributor.authorM. Logan, Richard
dc.contributor.authorNair, Raj
dc.contributor.authorM. Stringer, Andrea
dc.contributor.authorYazbeck, Roger
dc.contributor.authorElad, Sharon
dc.contributor.authorV. Lalla, Rajesh
dc.date.accessioned2017-05-03T15:14:14Z
dc.date.available2017-05-03T15:14:14Z
dc.date.issued2013
dc.date.modified2014-06-12T23:41:22Z
dc.identifier.issn0941-4355
dc.identifier.doi10.1007/s00520-013-1810-y
dc.identifier.urihttp://hdl.handle.net/10072/60087
dc.description.abstractBackground Considerable progress has been made in our understanding of the biological basis for cancer therapy-induced mucosal barrier injury (mucositis). The last formal review of the subject by MASCC/ISOO was published in 2007; consequently, an update is timely. Methods Panel members reviewed the biomedical literature on mucositis pathobiology published between January 2005 and December 2011. Results Recent research has provided data on the contribution of tissue structure changes, inflammation and microbiome changes to the development of mucositis. Additional research has focused on targeted therapy-induced toxicity, toxicity clustering and the investigation of genetic polymorphisms in toxicity prediction. This review paper summarizes the recent evidence on these aspects of mucositis pathobiology. Conclusion The ultimate goal of mucositis researchers is to identify the most appropriate targets for therapeutic interventions and to be able to predict toxicity risk and personalize interventions to genetically suitable patients. Continuing research efforts are needed to further our understanding of mucositis pathobiology and the pharmacogenomics of toxicity.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeGermany
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom2075
dc.relation.ispartofpageto2083
dc.relation.ispartofjournalSupportive Care in Cancer
dc.relation.ispartofvolume21
dc.rights.retentionY
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchCancer therapy (excl. chemotherapy and radiation therapy)
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchHealth sciences
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode321104
dc.subject.fieldofresearchcode52
dc.subject.fieldofresearchcode42
dc.titleEmerging evidence on the pathobiology of mucositis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorNair, Raj


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