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dc.contributor.authorHare, Kim M
dc.contributor.authorGrimwood, Keith
dc.contributor.authorLeach, Amanda J
dc.contributor.authorSmith-Vaughan, Heidi
dc.contributor.authorTorzillo, Paul J
dc.contributor.authorMorris, Peter S
dc.contributor.authorChang, Anne B
dc.date.accessioned2017-05-03T13:13:33Z
dc.date.available2017-05-03T13:13:33Z
dc.date.issued2010
dc.date.modified2014-06-12T23:42:17Z
dc.identifier.issn0022-3476
dc.identifier.doi10.1016/j.jpeds.2010.06.002
dc.identifier.urihttp://hdl.handle.net/10072/60113
dc.description.abstractObjective To test the hypothesis that bacterial density, strain diversity, and concordance of pathogens between upper and lower airways are higher in children with bronchiectasis than in those with non-bronchiectatic conditions. Study design Nasopharyngeal (NP) swabs and bronchoalveolar lavage (BAL) fluid were cultured from 45 Indigenous children with bronchiectasis and 30 non-Indigenous children with non-bronchiectatic respiratory symptoms. Lower airway infection was defined as >104 colony-forming units of respiratory bacteria/mL of BAL fluid. Concordance was determined by phenotype or genotype. Results NP carriage of Streptococcus pneumoniae, nontypable Haemophilus influenzae (NTHi), and Moraxella catarrhalis, and lower airway infection by NTHi (47% vs 3%), were detected significantly more often in the children with bronchiectasis than in those without this condition. BAL specimens from the infected Indigenous children also showed greater strain diversity (71% vs 0%). Strain concordance in NP and BAL cultures was high in both infected subgroups. Conclusions The high density and diversity of respiratory bacteria, along with strain concordance between upper and lower airways, found in Indigenous children with bronchiectasis suggest a possible pathogenic role of recurrent aspiration of NP secretions.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMosby
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1001
dc.relation.ispartofpageto1005
dc.relation.ispartofjournalJournal of Pediatrics
dc.relation.ispartofvolume157
dc.rights.retentionY
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchSports science and exercise not elsewhere classified
dc.subject.fieldofresearchReproductive medicine not elsewhere classified
dc.subject.fieldofresearchcode4207
dc.subject.fieldofresearchcode420799
dc.subject.fieldofresearchcode321599
dc.titleRespiratory Bacterial Pathogens in the Nasopharynx and Lower Airways of Australian Indigenous Children with Bronchiectasis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorGrimwood, Keith


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