dc.contributor.author | Major, LD | |
dc.contributor.author | Partridge, TS | |
dc.contributor.author | Gardner, J | |
dc.contributor.author | Kent, SJ | |
dc.contributor.author | de Rose, R | |
dc.contributor.author | Suhrbier, A | |
dc.contributor.author | Schroder, WA | |
dc.date.accessioned | 2018-01-12T01:21:11Z | |
dc.date.available | 2018-01-12T01:21:11Z | |
dc.date.issued | 2013 | |
dc.date.modified | 2014-06-17T04:49:02Z | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.doi | 10.1371/journal.pone.0057343 | |
dc.identifier.uri | http://hdl.handle.net/10072/60350 | |
dc.description.abstract | SerpinB2, also known as plasminogen activator inhibitor type 2, is a major product of activated monocytes/macrophages
and is often strongly induced during infection and inflammation; however, its physiological function remains somewhat
elusive. Herein we show that SerpinB2 is induced in peripheral blood mononuclear cells following infection of pigtail
macaques with CCR5-utilizing (macrophage-tropic) SIVmac239, but not the rapidly pathogenic CXCR4-utilizing (T cell-tropic)
SHIVmn229. To investigate the role of SerpinB2 in lentiviral infections, SerpinB22/2 mice were infected with EcoHIV, a chimeric
HIV in which HIV gp120 has been replaced with gp80 from ecotropic murine leukemia virus. EcoHIV infected SerpinB22/2
mice produced significantly lower anti-gag IgG1 antibody titres than infected SerpinB2+/+ mice, and showed slightly delayed
clearance of EcoHIV. Analyses of published microarray studies showed significantly higher levels of SerpinB2 mRNA in
monocytes from HIV-1 infected patients when compared with uninfected controls, as well as a significant negative
correlation between SerpinB2 and T-bet mRNA levels in peripheral blood mononuclear cells. These data illustrate that
SerpinB2 can be induced by lentiviral infection in vivo and support the emerging notion that a physiological role of
SerpinB2 is modulation of Th1/Th2 responses. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Public Library of Science | |
dc.publisher.place | United States | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | e57343-1 | |
dc.relation.ispartofpageto | e57343-7 | |
dc.relation.ispartofissue | 2 | |
dc.relation.ispartofjournal | PloS One | |
dc.relation.ispartofvolume | 8 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Immunology not elsewhere classified | |
dc.subject.fieldofresearchcode | 110799 | |
dc.title | Induction of SerpinB2 and Th1/Th2 Modulation by SerpinB2 during Lentiviral Infections In Vivo | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/ | |
dc.description.version | Version of Record (VoR) | |
gro.rights.copyright | ©
2013 Suhrbier et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Suhrbier, Andreas | |
gro.griffith.author | Schroder, Wayne | |