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dc.contributor.authorMajor, LD
dc.contributor.authorPartridge, TS
dc.contributor.authorGardner, J
dc.contributor.authorKent, SJ
dc.contributor.authorde Rose, R
dc.contributor.authorSuhrbier, A
dc.contributor.authorSchroder, WA
dc.date.accessioned2018-01-12T01:21:11Z
dc.date.available2018-01-12T01:21:11Z
dc.date.issued2013
dc.date.modified2014-06-17T04:49:02Z
dc.identifier.issn1932-6203
dc.identifier.doi10.1371/journal.pone.0057343
dc.identifier.urihttp://hdl.handle.net/10072/60350
dc.description.abstractSerpinB2, also known as plasminogen activator inhibitor type 2, is a major product of activated monocytes/macrophages and is often strongly induced during infection and inflammation; however, its physiological function remains somewhat elusive. Herein we show that SerpinB2 is induced in peripheral blood mononuclear cells following infection of pigtail macaques with CCR5-utilizing (macrophage-tropic) SIVmac239, but not the rapidly pathogenic CXCR4-utilizing (T cell-tropic) SHIVmn229. To investigate the role of SerpinB2 in lentiviral infections, SerpinB22/2 mice were infected with EcoHIV, a chimeric HIV in which HIV gp120 has been replaced with gp80 from ecotropic murine leukemia virus. EcoHIV infected SerpinB22/2 mice produced significantly lower anti-gag IgG1 antibody titres than infected SerpinB2+/+ mice, and showed slightly delayed clearance of EcoHIV. Analyses of published microarray studies showed significantly higher levels of SerpinB2 mRNA in monocytes from HIV-1 infected patients when compared with uninfected controls, as well as a significant negative correlation between SerpinB2 and T-bet mRNA levels in peripheral blood mononuclear cells. These data illustrate that SerpinB2 can be induced by lentiviral infection in vivo and support the emerging notion that a physiological role of SerpinB2 is modulation of Th1/Th2 responses.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageeng
dc.publisherPublic Library of Science
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrome57343-1
dc.relation.ispartofpagetoe57343-7
dc.relation.ispartofissue2
dc.relation.ispartofjournalPloS One
dc.relation.ispartofvolume8
dc.rights.retentionY
dc.subject.fieldofresearchImmunology not elsewhere classified
dc.subject.fieldofresearchcode110799
dc.titleInduction of SerpinB2 and Th1/Th2 Modulation by SerpinB2 during Lentiviral Infections In Vivo
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.description.versionPublished
gro.rights.copyright© 2013 Suhrbier et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
gro.hasfulltextFull Text
gro.griffith.authorSuhrbier, Andreas
gro.griffith.authorSchroder, Wayne


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