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dc.contributor.authorD. Major, Lee
dc.contributor.authorS. Partridge, Thomas
dc.contributor.authorGardner, Joy
dc.contributor.authorJ. Kent, Stephen
dc.contributor.authorRose, Robert
dc.contributor.authorSuhrbier, Andreas
dc.contributor.authorA. Schroder, Wayne
dc.date.accessioned2018-01-12T01:21:11Z
dc.date.available2018-01-12T01:21:11Z
dc.date.issued2013
dc.date.modified2014-06-17T04:49:02Z
dc.identifier.issn19326203en_US
dc.identifier.doi10.1371/journal.pone.0057343en_US
dc.identifier.urihttp://hdl.handle.net/10072/60350
dc.description.abstractSerpinB2, also known as plasminogen activator inhibitor type 2, is a major product of activated monocytes/macrophages and is often strongly induced during infection and inflammation; however, its physiological function remains somewhat elusive. Herein we show that SerpinB2 is induced in peripheral blood mononuclear cells following infection of pigtail macaques with CCR5-utilizing (macrophage-tropic) SIVmac239, but not the rapidly pathogenic CXCR4-utilizing (T cell-tropic) SHIVmn229. To investigate the role of SerpinB2 in lentiviral infections, SerpinB22/2 mice were infected with EcoHIV, a chimeric HIV in which HIV gp120 has been replaced with gp80 from ecotropic murine leukemia virus. EcoHIV infected SerpinB22/2 mice produced significantly lower anti-gag IgG1 antibody titres than infected SerpinB2+/+ mice, and showed slightly delayed clearance of EcoHIV. Analyses of published microarray studies showed significantly higher levels of SerpinB2 mRNA in monocytes from HIV-1 infected patients when compared with uninfected controls, as well as a significant negative correlation between SerpinB2 and T-bet mRNA levels in peripheral blood mononuclear cells. These data illustrate that SerpinB2 can be induced by lentiviral infection in vivo and support the emerging notion that a physiological role of SerpinB2 is modulation of Th1/Th2 responses.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.publisherPublic Library of Scienceen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrome57343-1en_US
dc.relation.ispartofpagetoe57343-7en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalPloS Oneen_US
dc.relation.ispartofvolume8en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchImmunology not elsewhere classifieden_US
dc.subject.fieldofresearchcode110799en_US
dc.titleInduction of SerpinB2 and Th1/Th2 Modulation by SerpinB2 during Lentiviral Infections In Vivoen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/en_US
dc.description.versionPublisheden_US
gro.rights.copyright© 2013 Suhrbier et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
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