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dc.contributor.authorLewohl, JM
dc.contributor.authorWang, L
dc.contributor.authorMiles, MF
dc.contributor.authorZhang, L
dc.contributor.authorDodd, PR
dc.contributor.authorHarris, RA
dc.date.accessioned2006-07-10
dc.date.accessioned2014-06-17T04:50:01Z
dc.date.accessioned2017-03-02T00:47:37Z
dc.date.available2017-03-02T00:47:37Z
dc.date.issued2000
dc.date.modified2014-06-17T04:50:01Z
dc.identifier.issn0145-6008
dc.identifier.doi10.1111/j.1530-0277.2000.tb01993.x
dc.identifier.urihttp://hdl.handle.net/10072/60379
dc.description.abstractBackground: Changes in brain gene expression are thought to be responsible for the tolerance, dependence, and neurotoxicity produced by chronic alcohol abuse, but there has been no large scale study of gene expression in human alcoholism. Methods: RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. We used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Results: Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics. Analysis of these changes revealed a selective reprogramming of gene expression in this brain region, particularly for myelin-related genes which were down-regulated in the alcoholic samples. In addition, cell cycle genes and several neuronal genes were changed in expression. Conclusions: These gene expression changes suggest a mechanism for the loss of cerebral white matter in alcoholics as well as alterations that may lead to the neurotoxic actions of ethanol.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.publisherWilliams And Wilkins
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom1873
dc.relation.ispartofpageto1882
dc.relation.ispartofissue12
dc.relation.ispartofjournalAlcoholism, clinical and experimental research
dc.relation.ispartofvolume24
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1701
dc.titleGene expression in human alcoholism: Microarray analysis of frontal cortex
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codec1x
gro.facultyGriffith Health Faculty
gro.hasfulltextNo Full Text
gro.griffith.authorLewohl, Joanne M.
gro.griffith.authorDodd, Peter


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