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  • Molecular epidemiology of enterovirus 71 over two decades in an Australian urban community

    Author(s)
    Sanders, SA
    Herrero, LJ
    McPhie, K
    Chow, SSW
    Craig, ME
    Dwyer, DE
    Rawlinson, W
    McMinn, PC
    Griffith University Author(s)
    Herrero, Lara J.
    Year published
    2006
    Metadata
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    Abstract
    Enterovirus 71 (EV71), first isolated in 1969, has been responsible for numerous outbreaks of hand, foot and mouth disease (HFMD) with a small proportion of cases associated with neurological disease. Since 1997 there has been a significant increase in both the prevalence and virulence of EV71 in the Asia-Pacific region. We have examined the genetic diversity of EV71 in a large Australian city (Sydney N.S.W.) over a nineteen-year period. We determined the VP1 gene sequence of forty-eight EV71 strains isolated between 1983 and 2001. Analysis by molecular phylogeny revealed the presence of four subgenogroups B2, B4, C1 and C2. ...
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    Enterovirus 71 (EV71), first isolated in 1969, has been responsible for numerous outbreaks of hand, foot and mouth disease (HFMD) with a small proportion of cases associated with neurological disease. Since 1997 there has been a significant increase in both the prevalence and virulence of EV71 in the Asia-Pacific region. We have examined the genetic diversity of EV71 in a large Australian city (Sydney N.S.W.) over a nineteen-year period. We determined the VP1 gene sequence of forty-eight EV71 strains isolated between 1983 and 2001. Analysis by molecular phylogeny revealed the presence of four subgenogroups B2, B4, C1 and C2. The results indicate that the major lineage circulating in Sydney N.S.W. was subgenogroup C1 with a recent switch in dominance to B4 in 2000 and 2001
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    Journal Title
    Archives of Virology
    Volume
    151
    Issue
    5
    DOI
    https://doi.org/10.1007/s00705-005-0684-9
    Subject
    Biological sciences
    Virology
    Agricultural, veterinary and food sciences
    Biomedical and clinical sciences
    Publication URI
    http://hdl.handle.net/10072/60419
    Collection
    • Journal articles

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