dc.contributor.author | Rodriguez, Astrid | |
dc.contributor.author | Maher, Bridget | |
dc.contributor.author | Lea, Rodney | |
dc.contributor.author | Benton, Miles | |
dc.contributor.author | Griffiths, Lyn | |
dc.date.accessioned | 2017-05-03T13:14:05Z | |
dc.date.available | 2017-05-03T13:14:05Z | |
dc.date.issued | 2013 | |
dc.date.modified | 2014-06-18T05:54:07Z | |
dc.identifier.issn | 14682982 | |
dc.identifier.doi | 10.1177/0333102413486321 | |
dc.identifier.uri | http://hdl.handle.net/10072/60490 | |
dc.description.abstract | Background Oestrogen receptor 1 (ESR1) is located in region 6q25.1 and encodes a ligand-activated transcription factor composed of several domains important for hormone binding and transcription activation. Progesterone receptor (PGR) is located in 11q22-23 and mediates the role of progesterone interacting with different transcriptional co-regulators. ESR1 and PGR have previously been implicated in migraine susceptibility. Here, we report the results of an association study of these genes in a migraine pedigree from the genetic isolate of Norfolk Island, a population descended from a small number of Isle of Man "Bounty Mutineer" and Tahitian founders. Methods A significant number of molecular markers in the ESR1 (143) and PGR (43) genes were evaluated in a sample of 285 related individuals (135 males; 150 females). A pedigree-based analysis in the GenABEL package was used to analyse the results. Results and conclusions A total of 10 markers in the ESR1 gene showed association with migraine (p?<?0.05) in the Norfolk Island population. No association was detected with PGR. Three haplotypes in ESR1 were found to be associated with migraine (p?=?0.004, 0.03, 0.005). Future genetic studies in larger populations and expression analysis are required to clarify the role of ESR1 in migraine susceptibility. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Sage | |
dc.publisher.place | United Kingdom | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 1139 | |
dc.relation.ispartofpageto | 1147 | |
dc.relation.ispartofissue | 14 | |
dc.relation.ispartofjournal | Cephalalgia | |
dc.relation.ispartofvolume | 33 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Clinical Sciences not elsewhere classified | |
dc.subject.fieldofresearch | Neurosciences not elsewhere classified | |
dc.subject.fieldofresearch | Clinical Sciences | |
dc.subject.fieldofresearch | Neurosciences | |
dc.subject.fieldofresearchcode | 110399 | |
dc.subject.fieldofresearchcode | 110999 | |
dc.subject.fieldofresearchcode | 1103 | |
dc.subject.fieldofresearchcode | 1109 | |
dc.title | Association of oestrogen-receptor gene (ESR1) polymorphisms with migraine in the large Norfolk Island pedigree | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | Griffith Health, School of Medical Science | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Griffiths, Lyn | |
gro.griffith.author | Lea, Rodney A. | |
gro.griffith.author | Maher, Bridget | |
gro.griffith.author | Benton, Miles | |
gro.griffith.author | Rodriguez Acevedo, Astrid | |