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dc.contributor.authorRodriguez, Astrid
dc.contributor.authorMaher, Bridget
dc.contributor.authorLea, Rodney
dc.contributor.authorBenton, Miles
dc.contributor.authorGriffiths, Lyn
dc.date.accessioned2017-05-03T13:14:05Z
dc.date.available2017-05-03T13:14:05Z
dc.date.issued2013
dc.date.modified2014-06-18T05:54:07Z
dc.identifier.issn14682982
dc.identifier.doi10.1177/0333102413486321
dc.identifier.urihttp://hdl.handle.net/10072/60490
dc.description.abstractBackground Oestrogen receptor 1 (ESR1) is located in region 6q25.1 and encodes a ligand-activated transcription factor composed of several domains important for hormone binding and transcription activation. Progesterone receptor (PGR) is located in 11q22-23 and mediates the role of progesterone interacting with different transcriptional co-regulators. ESR1 and PGR have previously been implicated in migraine susceptibility. Here, we report the results of an association study of these genes in a migraine pedigree from the genetic isolate of Norfolk Island, a population descended from a small number of Isle of Man "Bounty Mutineer" and Tahitian founders. Methods A significant number of molecular markers in the ESR1 (143) and PGR (43) genes were evaluated in a sample of 285 related individuals (135 males; 150 females). A pedigree-based analysis in the GenABEL package was used to analyse the results. Results and conclusions A total of 10 markers in the ESR1 gene showed association with migraine (p?<?0.05) in the Norfolk Island population. No association was detected with PGR. Three haplotypes in ESR1 were found to be associated with migraine (p?=?0.004, 0.03, 0.005). Future genetic studies in larger populations and expression analysis are required to clarify the role of ESR1 in migraine susceptibility.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSage
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1139
dc.relation.ispartofpageto1147
dc.relation.ispartofissue14
dc.relation.ispartofjournalCephalalgia
dc.relation.ispartofvolume33
dc.rights.retentionY
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchNeurosciences not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode110399
dc.subject.fieldofresearchcode110999
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1109
dc.titleAssociation of oestrogen-receptor gene (ESR1) polymorphisms with migraine in the large Norfolk Island pedigree
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.hasfulltextNo Full Text
gro.griffith.authorGriffiths, Lyn
gro.griffith.authorLea, Rodney A.
gro.griffith.authorMaher, Bridget
gro.griffith.authorBenton, Miles
gro.griffith.authorRodriguez Acevedo, Astrid


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