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  • Bioreactor Design for Tendon/Ligament Engineering

    Author
    Wang, Tao
    Gardiner, Bruce S.
    Lin, Zhen
    Rubenson, Jonas
    Kirk, Thomas B.
    Wang, Allan
    Xu, Jiake
    Smith, David W.
    Lloyd, David
    Zheng, Ming H.
    Year published
    2013
    Metadata
    Show full item record
    Abstract
    Tendon and ligament injury is a worldwide health problem, but the treatment options remain limited. Tendon and ligament engineering might provide an alternative tissue source for the surgical replacement of injured tendon. A bioreactor provides a controllable environment enabling the systematic study of specific biological, biochemical, and biomechanical requirements to design and manufacture engineered tendon/ligament tissue. Furthermore, the tendon/ligament bioreactor system can provide a suitable culture environment, which mimics the dynamics of the in vivo environment for tendon/ligament maturation. For clinical settings, ...
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    Tendon and ligament injury is a worldwide health problem, but the treatment options remain limited. Tendon and ligament engineering might provide an alternative tissue source for the surgical replacement of injured tendon. A bioreactor provides a controllable environment enabling the systematic study of specific biological, biochemical, and biomechanical requirements to design and manufacture engineered tendon/ligament tissue. Furthermore, the tendon/ligament bioreactor system can provide a suitable culture environment, which mimics the dynamics of the in vivo environment for tendon/ligament maturation. For clinical settings, bioreactors also have the advantages of less-contamination risk, high reproducibility of cell propagation by minimizing manual operation, and a consistent end product. In this review, we identify the key components, design preferences, and criteria that are required for the development of an ideal bioreactor for engineering tendons and ligaments.
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    Journal Title
    Tissue Engineering
    Volume
    19
    Issue
    2
    DOI
    https://doi.org/10.1089/ten.teb.2012.0295
    Subject
    Biomedical Engineering not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/60541
    Collection
    • Journal articles

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