dc.contributor.author | Wang, Tao | |
dc.contributor.author | Gardiner, Bruce S | |
dc.contributor.author | Lin, Zhen | |
dc.contributor.author | Rubenson, Jonas | |
dc.contributor.author | Kirk, Thomas B | |
dc.contributor.author | Wang, Allan | |
dc.contributor.author | Xu, Jiake | |
dc.contributor.author | Smith, David W | |
dc.contributor.author | Lloyd, David G | |
dc.contributor.author | Zheng, Ming H | |
dc.date.accessioned | 2017-05-03T12:44:10Z | |
dc.date.available | 2017-05-03T12:44:10Z | |
dc.date.issued | 2013 | |
dc.date.modified | 2014-06-18T05:56:30Z | |
dc.identifier.issn | 1937-3368 | |
dc.identifier.doi | 10.1089/ten.teb.2012.0295 | |
dc.identifier.uri | http://hdl.handle.net/10072/60541 | |
dc.description.abstract | Tendon and ligament injury is a worldwide health problem, but the treatment options remain limited. Tendon and ligament engineering might provide an alternative tissue source for the surgical replacement of injured tendon. A bioreactor provides a controllable environment enabling the systematic study of specific biological, biochemical, and biomechanical requirements to design and manufacture engineered tendon/ligament tissue. Furthermore, the tendon/ligament bioreactor system can provide a suitable culture environment, which mimics the dynamics of the in vivo environment for tendon/ligament maturation. For clinical settings, bioreactors also have the advantages of less-contamination risk, high reproducibility of cell propagation by minimizing manual operation, and a consistent end product. In this review, we identify the key components, design preferences, and criteria that are required for the development of an ideal bioreactor for engineering tendons and ligaments. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Mary Ann Liebert | |
dc.publisher.place | United States | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 133 | |
dc.relation.ispartofpageto | 146 | |
dc.relation.ispartofissue | 2 | |
dc.relation.ispartofjournal | Tissue Engineering | |
dc.relation.ispartofvolume | 19 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Biochemistry and cell biology | |
dc.subject.fieldofresearch | Biomedical engineering | |
dc.subject.fieldofresearch | Biomedical engineering not elsewhere classified | |
dc.subject.fieldofresearchcode | 3101 | |
dc.subject.fieldofresearchcode | 4003 | |
dc.subject.fieldofresearchcode | 400399 | |
dc.title | Bioreactor Design for Tendon/Ligament Engineering | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Lloyd, David | |