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dc.contributor.authorWang, Tao
dc.contributor.authorGardiner, Bruce S
dc.contributor.authorLin, Zhen
dc.contributor.authorRubenson, Jonas
dc.contributor.authorKirk, Thomas B
dc.contributor.authorWang, Allan
dc.contributor.authorXu, Jiake
dc.contributor.authorSmith, David W
dc.contributor.authorLloyd, David G
dc.contributor.authorZheng, Ming H
dc.date.accessioned2017-05-03T12:44:10Z
dc.date.available2017-05-03T12:44:10Z
dc.date.issued2013
dc.date.modified2014-06-18T05:56:30Z
dc.identifier.issn1937-3368
dc.identifier.doi10.1089/ten.teb.2012.0295
dc.identifier.urihttp://hdl.handle.net/10072/60541
dc.description.abstractTendon and ligament injury is a worldwide health problem, but the treatment options remain limited. Tendon and ligament engineering might provide an alternative tissue source for the surgical replacement of injured tendon. A bioreactor provides a controllable environment enabling the systematic study of specific biological, biochemical, and biomechanical requirements to design and manufacture engineered tendon/ligament tissue. Furthermore, the tendon/ligament bioreactor system can provide a suitable culture environment, which mimics the dynamics of the in vivo environment for tendon/ligament maturation. For clinical settings, bioreactors also have the advantages of less-contamination risk, high reproducibility of cell propagation by minimizing manual operation, and a consistent end product. In this review, we identify the key components, design preferences, and criteria that are required for the development of an ideal bioreactor for engineering tendons and ligaments.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMary Ann Liebert
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom133
dc.relation.ispartofpageto146
dc.relation.ispartofissue2
dc.relation.ispartofjournalTissue Engineering
dc.relation.ispartofvolume19
dc.rights.retentionY
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchBiomedical engineering not elsewhere classified
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode4003
dc.subject.fieldofresearchcode400399
dc.titleBioreactor Design for Tendon/Ligament Engineering
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorLloyd, David


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