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  • Elution and mechanical properties of antifungal bone cement.

    Author(s)
    Goss, Ben
    Lutton, Cameron
    Weinrauch, Patrick
    Jabur, Majid
    Gillett, Greg
    Crawford, Ross
    Griffith University Author(s)
    Weinrauch, Patrick C.
    Year published
    2007
    Metadata
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    Abstract
    The effect of the incorporation of amphotericin B into bone cement was examined; as literature suggests, this may be a feasible method for the treatment of periprosthetic fungal infections. Addition of antifungal increased the compressive strength of the bone cement--a statistically significant amount from 107 +/- 2.3 to 121 +/- 1.5 MPa. Elution of tobramycin and amphotericin B was quantified using ultraviolet-visible spectroscopy. Spectroscopy showed that 18% of the antibiotic was released during the first week, with most released in the first 24 hours. The elution of antifungal, however, was unable to be detected after 1 ...
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    The effect of the incorporation of amphotericin B into bone cement was examined; as literature suggests, this may be a feasible method for the treatment of periprosthetic fungal infections. Addition of antifungal increased the compressive strength of the bone cement--a statistically significant amount from 107 +/- 2.3 to 121 +/- 1.5 MPa. Elution of tobramycin and amphotericin B was quantified using ultraviolet-visible spectroscopy. Spectroscopy showed that 18% of the antibiotic was released during the first week, with most released in the first 24 hours. The elution of antifungal, however, was unable to be detected after 1 week, with less than 0.03% released. Amphotericin B does not weaken bone cement. Its inability to be delivered at a clinically significant dose gives no clear indication for its incorporation into cement.
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    Journal Title
    Journal of Arthroplasty
    Volume
    22
    Issue
    6
    DOI
    https://doi.org/10.1016/j.arth.2006.09.013
    Subject
    Biomedical engineering
    Clinical sciences
    Publication URI
    http://hdl.handle.net/10072/60555
    Collection
    • Journal articles

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