Show simple item record

dc.contributor.authorButterworth, Alice S
dc.contributor.authorSkinner-Adams, Tina S
dc.contributor.authorGardiner, Don L
dc.contributor.authorTrenholme, Katharine R
dc.date.accessioned2018-05-03T01:00:26Z
dc.date.available2018-05-03T01:00:26Z
dc.date.issued2013
dc.identifier.issn0031-1820
dc.identifier.doi10.1017/S0031182013001236
dc.identifier.urihttp://hdl.handle.net/10072/60570
dc.description.abstractDrugs that kill or inhibit the sexual stages of Plasmodium in order to prevent transmission are important components of malaria control programmes. Reducing gametocyte carriage is central to the control of Plasmodium falciparum transmission as infection can result in extended periods of gametocytaemia. Unfortunately the number of drugs with activity against gametocytes is limited. Primaquine is currently the only licensed drug with activity against the sexual stages of malaria parasites and its use is hampered by safety concerns. This shortcoming is likely the result of the technical challenges associated with gametocyte studies together with the focus of previous drug discovery campaigns on asexual parasite stages. However recent emphasis on malaria eradication has resulted in an upsurge of interest in identifying compounds with activity against gametocytes. This review examines the gametocytocidal properties of currently available drugs as well as those in the development pipeline and examines the prospects for discovery of new anti-gametocyte compounds.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent216477 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoen_US
dc.publisherCambridge University Press
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1718
dc.relation.ispartofpageto1734
dc.relation.ispartofjournalParasitology
dc.relation.ispartofvolume140
dc.rights.retentionY
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchVeterinary Sciences
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode0707
dc.titlePlasmodium falciparum gametocytes: with a view to a kill
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2013 Cambridge University Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2014-12-10T21:44:30Z
gro.hasfulltextFull Text
gro.griffith.authorSkinner-Adams, Tina
gro.griffith.authorGardiner, Donald
gro.griffith.authorTrenholme, Katharine


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record