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  • Vancomycin in the treatment of meticillin-resistant Staphylococcus aureus (MRSA) infection: End of an era?

    Author(s)
    Bal, AM
    Garau, J
    Gould, IM
    Liao, CH
    Mazzei, T
    Nimmo, GR
    Soriano, A
    Stefani, S
    Tenover, FC
    Griffith University Author(s)
    Nimmo, Graeme R.
    Year published
    2013
    Metadata
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    Abstract
    Infection with meticillin-resistant Staphylococcus aureus (MRSA) continues to have significant morbidity and mortality. Vancomycin, which has been the mainstay of treatment of invasive MRSA infections, has several drawbacks related to its pharmacological properties as well as varying degrees of emerging resistance. These resistant subpopulations are difficult to detect, making therapy with vancomycin less reliable. The newer agents such as linezolid, daptomycin, ceftaroline, and the newer glycopeptides telavancin and oritavancin are useful alternatives that could potentially replace vancomycin in the treatment of certain ...
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    Infection with meticillin-resistant Staphylococcus aureus (MRSA) continues to have significant morbidity and mortality. Vancomycin, which has been the mainstay of treatment of invasive MRSA infections, has several drawbacks related to its pharmacological properties as well as varying degrees of emerging resistance. These resistant subpopulations are difficult to detect, making therapy with vancomycin less reliable. The newer agents such as linezolid, daptomycin, ceftaroline, and the newer glycopeptides telavancin and oritavancin are useful alternatives that could potentially replace vancomycin in the treatment of certain conditions. By summarising the discussions that took place at the III MRSA Consensus Conference in relation to the current place of vancomycin in therapy and the potential of the newer agents to replace vancomycin, this review focuses on the challenges faced by the laboratory and by clinicians in the diagnosis and treatment of MRSA infections.
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    Journal Title
    Journal of Global Antimicrobial Resistance
    Volume
    1
    Issue
    1
    DOI
    https://doi.org/10.1016/j.jgar.2013.01.002
    Subject
    Microbiology not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/60616
    Collection
    • Journal articles

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