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dc.contributor.authorMoyle, Peter Michaelen_US
dc.contributor.authorOlive, Colleenen_US
dc.contributor.authorKarpati, Leventeen_US
dc.contributor.authorBarozzi, Nadiaen_US
dc.contributor.authorHo, Mei-Fongen_US
dc.contributor.authorDyer, Joanneen_US
dc.contributor.authorSun, Hsien Kuoen_US
dc.contributor.authorGood, Michaelen_US
dc.contributor.authorToth, Istvanen_US
dc.date.accessioned2017-05-03T14:53:56Z
dc.date.available2017-05-03T14:53:56Z
dc.date.issued2006en_US
dc.date.modified2014-06-19T22:41:42Z
dc.identifier.issn15733149en_US
dc.identifier.doi10.1007/s10989-006-9021-8en_US
dc.identifier.urihttp://hdl.handle.net/10072/60629
dc.description.abstractGroup A streptococcus (GAS) is responsible for causing many clinical complications including the relatively benign streptococcal pharyngitis and impetigo. However, if left untreated, these conditions may lead to more severe diseases such as rheumatic fever (RF) and rheumatic heart disease (RHD). These diseases exhibit high morbidity and mortality, particularly in developing countries and in indigenous populations of affluent countries. As RF and RHD only ever occur following GAS infection, a vaccine offers promise for their prevention. As such, we have investigated the use of the lipid-core peptide (LCP) system for the development of multi-valent prophylactic GAS vaccines. The current study has investigated the capacity of this system to adjuvant up to four different GAS peptide epitopes. Presented are the synthesis and immunological assessment of tetra-valent and tri-valent GAS LCP systems. We demonstrated their capacity to elicit systemic IgG antibody responses in B10.BR mice to all GAS peptide epitopes. The data also showed that the LCP systems were self-adjuvanting. These findings are particularly encouraging for the development of multi-valent LCP-based GAS vaccines.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.publisherSpringer Netherlandsen_US
dc.publisher.placeNetherlandsen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom317en_US
dc.relation.ispartofpageto326en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalInternational Journal of Peptide Research and Therapeuticsen_US
dc.relation.ispartofvolume12en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchMedical Biochemistry and Metabolomics not elsewhere classifieden_US
dc.subject.fieldofresearchcode110199en_US
dc.titleSynthesis and Immunological Evaluation of M Protein Targeted Tetra-Valent and Tri-Valent Group A Streptococcal Vaccine Candidates Based on the Lipid-Core Peptide Systemen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.hasfulltextNo Full Text
gro.griffith.authorGood, Michael F.


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