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dc.contributor.authorMoyle, Peter Michael
dc.contributor.authorOlive, Colleen
dc.contributor.authorKarpati, Levente
dc.contributor.authorBarozzi, Nadia
dc.contributor.authorHo, Mei-Fong
dc.contributor.authorDyer, Joanne
dc.contributor.authorSun, Hsien Kuo
dc.contributor.authorGood, Michael
dc.contributor.authorToth, Istvan
dc.date.accessioned2017-05-03T14:53:56Z
dc.date.available2017-05-03T14:53:56Z
dc.date.issued2006
dc.date.modified2014-06-19T22:41:42Z
dc.identifier.issn15733149
dc.identifier.doi10.1007/s10989-006-9021-8
dc.identifier.urihttp://hdl.handle.net/10072/60629
dc.description.abstractGroup A streptococcus (GAS) is responsible for causing many clinical complications including the relatively benign streptococcal pharyngitis and impetigo. However, if left untreated, these conditions may lead to more severe diseases such as rheumatic fever (RF) and rheumatic heart disease (RHD). These diseases exhibit high morbidity and mortality, particularly in developing countries and in indigenous populations of affluent countries. As RF and RHD only ever occur following GAS infection, a vaccine offers promise for their prevention. As such, we have investigated the use of the lipid-core peptide (LCP) system for the development of multi-valent prophylactic GAS vaccines. The current study has investigated the capacity of this system to adjuvant up to four different GAS peptide epitopes. Presented are the synthesis and immunological assessment of tetra-valent and tri-valent GAS LCP systems. We demonstrated their capacity to elicit systemic IgG antibody responses in B10.BR mice to all GAS peptide epitopes. The data also showed that the LCP systems were self-adjuvanting. These findings are particularly encouraging for the development of multi-valent LCP-based GAS vaccines.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer Netherlands
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom317
dc.relation.ispartofpageto326
dc.relation.ispartofissue3
dc.relation.ispartofjournalInternational Journal of Peptide Research and Therapeutics
dc.relation.ispartofvolume12
dc.rights.retentionY
dc.subject.fieldofresearchMedical Biochemistry and Metabolomics not elsewhere classified
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchMedical Biochemistry and Metabolomics
dc.subject.fieldofresearchcode110199
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1101
dc.titleSynthesis and Immunological Evaluation of M Protein Targeted Tetra-Valent and Tri-Valent Group A Streptococcal Vaccine Candidates Based on the Lipid-Core Peptide System
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorGood, Michael F.


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