Show simple item record

dc.contributor.authorTamara Perchyonok, V.
dc.contributor.authorZhang, Shengmiao
dc.contributor.authorOberholzer, Theunis
dc.date.accessioned2017-05-03T12:44:25Z
dc.date.available2017-05-03T12:44:25Z
dc.date.issued2013
dc.date.modified2014-06-23T03:59:24Z
dc.identifier.issn15672018
dc.identifier.doi10.2174/1567201811310010020
dc.identifier.urihttp://hdl.handle.net/10072/60821
dc.description.abstractIn this study we developed and evaluated a prototype of an effective occlusive mucoadhesive system for prophylaxis and/or treatment of oral mucositis based on chitosan and gelatine models together with nystatin as a prophylactic agent incorporated into the formulation and investigated drug release in-vitro. Results of in vitro studies showed that chitosan and gelatine based gels posses properties that makes them excellent candidates for treatment of oral mucositis. These properties include not only the palliative effects of an occlusive dressing but also the potential for delivering therapeutic compounds with chitosan gels providing drug concentrations above their minimum inhibition concentration and extending the retention time in the oral cavity due to their bioadhesive properties. Chitosan also offers an advantage over suspensions because of its inherent antimicrobial properties. The performance of gelatin-based gels highlights the novel, non-toxic, in situ forming gelatine based hydrogel. The results of in vitro drug release experiments demonstrated that all the hydrogel showed sustained release properties.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBentham Science Publishers
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom144
dc.relation.ispartofpageto150
dc.relation.ispartofissue1
dc.relation.ispartofjournalCurrent Drug Delivery
dc.relation.ispartofvolume10
dc.rights.retentionY
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences not elsewhere classified
dc.subject.fieldofresearchcode3214
dc.subject.fieldofresearchcode321499
dc.titleChitosan and Gelatin based Prototype Delivery Systems for the Treatment of Oral Mucositis: from Material to Performance in vitro
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorOberholzer, Theunis


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record