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  • Shared Pseudomonas aeruginosa genotypes are common in Australian cystic fibrosis centres

    Author(s)
    Kidd, Timothy J
    Ramsay, Kay A
    Hu, Honghua
    Marks, Guy B
    Wainwright, Claire E
    Bye, Peter T
    Elkins, Mark R
    Robinson, Philip J
    Rose, Barbara R
    Wilson, John W
    Grimwood, Keith
    Bell, Scott C
    Griffith University Author(s)
    Grimwood, Keith
    Year published
    2013
    Metadata
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    Abstract
    Recent molecular-typing studies suggest cross-infection as one of the potential acquisition pathways for Pseudomonas aeruginosa in patients with cystic fibrosis (CF). In Australia, there is only limited evidence of unrelated patients sharing indistinguishable P. aeruginosa strains. We therefore examined the point-prevalence, distribution, diversity and clinical impact of P. aeruginosa strains in Australian CF patients nationally. 983 patients attending 18 Australian CF centres provided 2887 sputum P. aeruginosa isolates for genotyping by enterobacterial repetitive intergenic consensus-PCR assays with confirmation by multilocus ...
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    Recent molecular-typing studies suggest cross-infection as one of the potential acquisition pathways for Pseudomonas aeruginosa in patients with cystic fibrosis (CF). In Australia, there is only limited evidence of unrelated patients sharing indistinguishable P. aeruginosa strains. We therefore examined the point-prevalence, distribution, diversity and clinical impact of P. aeruginosa strains in Australian CF patients nationally. 983 patients attending 18 Australian CF centres provided 2887 sputum P. aeruginosa isolates for genotyping by enterobacterial repetitive intergenic consensus-PCR assays with confirmation by multilocus sequence typing. Demographic and clinical details were recorded for each participant. Overall, 610 (62%) patients harboured at least one of 38 shared genotypes. Most shared strains were in small patient clusters from a limited number of centres. However, the two predominant genotypes, AUST-01 and AUST-02, were widely dispersed, being detected in 220 (22%) and 173 (18%) patients attending 17 and 16 centres, respectively. AUST-01 was associated with significantly greater treatment requirements than unique P. aeruginosa strains. Multiple clusters of shared P. aeruginosa strains are common in Australian CF centres. At least one of the predominant and widespread genotypes is associated with increased healthcare utilisation. Longitudinal studies are now needed to determine the infection control implications of these findings.
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    Journal Title
    The European Respiratory Journal
    Volume
    41
    Issue
    5
    DOI
    https://doi.org/10.1183/09031936.00060512
    Copyright Statement
    Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
    Subject
    Biological Sciences not elsewhere classified
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/60865
    Collection
    • Journal articles

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