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  • Rare cell isolation and analysis in microfluidics

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    91755_1.pdf (666.6Kb)
    Author(s)
    Chen, Yuchao
    Li, Peng
    Huang, Po-Hsun
    Xie, Yuliang
    Mai, John D
    Wang, Lin
    Nam-Trung, Nguyen
    Huang, Tony Jun
    Griffith University Author(s)
    Nguyen, Nam-Trung
    Year published
    2014
    Metadata
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    Abstract
    Rare cells are low-abundance cells in a much larger population of background cells. Conventional benchtop techniques have limited capabilities to isolate and analyze rare cells because of their generally low selectivity and significant sample loss. Recent rapid advances in microfluidics have been providing robust solutions to the challenges in the isolation and analysis of rare cells. In addition to the apparent performance enhancements resulting in higher efficiencies and sensitivity levels, microfluidics provides other advanced features such as simpler handling of small sample volumes and multiplexing capabilities for ...
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    Rare cells are low-abundance cells in a much larger population of background cells. Conventional benchtop techniques have limited capabilities to isolate and analyze rare cells because of their generally low selectivity and significant sample loss. Recent rapid advances in microfluidics have been providing robust solutions to the challenges in the isolation and analysis of rare cells. In addition to the apparent performance enhancements resulting in higher efficiencies and sensitivity levels, microfluidics provides other advanced features such as simpler handling of small sample volumes and multiplexing capabilities for high-throughput processing. All of these advantages make microfluidics an excellent platform to deal with the transport, isolation, and analysis of rare cells. Various cellular biomarkers, including physical properties, dielectric properties, as well as immunoaffinities, have been explored for isolating rare cells. In this Focus article, we discuss the design considerations of representative microfluidic devices for rare cell isolation and analysis. Examples from recently published works are discussed to highlight the advantages and limitations of the different techniques. Various applications of these techniques are then introduced. Finally, a perspective on the development trends and promising research directions in this field are proposed.
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    Journal Title
    Lab on a Chip
    Volume
    14
    Issue
    4
    DOI
    https://doi.org/10.1039/C3LC90136J
    Copyright Statement
    © 2014 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
    Subject
    Chemical sciences
    Engineering
    Engineering practice and education not elsewhere classified
    Cancer diagnosis
    Publication URI
    http://hdl.handle.net/10072/61108
    Collection
    • Journal articles

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