Engineering microfluidic concentration gradient generators for biological applications
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This paper reviews the latest developments in the design and fabrication of concentration gradient generators for microfluidics-based biological applications. New gradient generator designs and their underlying mass transport principles are discussed. The review provides a blueprint for design considerations of concentration gradients in different applications, specifically biological studies. The paper discusses the basic phenomena associated with microfluidic gradient generation and the different gradient generation modes used in static and dynamic biological assays. Finally, the paper summarizes all factors to consider when using concentration gradient generators and puts forward perspectives on the future development of these devices.
Microfluidics and Nanofluidics
© 2014 Springer Berlin Heidelberg. This is an electronic version of an article published in Microfluidics and Nanofluidics, Vol. 16(1-2), pp. 1-18, 2014. Microfluidics and Nanofluidics is available online at: http://link.springer.com/ with the open URL of your article.
Interdisciplinary Engineering not elsewhere classified