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  • Syntheses and pharmacokinetics properties of an iloperidone pharmaceutical cocrystal

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    Author(s)
    Zhang, Ting-Ting
    Wang, Hai-Tao
    Jia, Jiang-Tao
    Cui, Xiao-Qiang
    Li, Qin
    Zhu, Guang-Shan
    Griffith University Author(s)
    Li, Qin
    Year published
    2014
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    Abstract
    We report here a pharmaceutical cocrystal, which was composed of iloperidone with 3, 5-pyridinedicarboxlic acid by crystal engineering strategy. It was characterized by single crystal X-ray and powder X-ray diffraction, which demonstrated that the cocrystal with high purity was obtained. Pharmacokinetics (PK) study of Jilin Uni- versity China-Cocrystal 10 (JUC-C10) was performed to evaluate the advantages of this strategy for enhancing the oral absorption of the original active pharmaceutical ingredient (API) of iloperidone. The in vivo study of Beagle dogs revealed that the plasma concentration of JUC-C10 reached the maximum ...
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    We report here a pharmaceutical cocrystal, which was composed of iloperidone with 3, 5-pyridinedicarboxlic acid by crystal engineering strategy. It was characterized by single crystal X-ray and powder X-ray diffraction, which demonstrated that the cocrystal with high purity was obtained. Pharmacokinetics (PK) study of Jilin Uni- versity China-Cocrystal 10 (JUC-C10) was performed to evaluate the advantages of this strategy for enhancing the oral absorption of the original active pharmaceutical ingredient (API) of iloperidone. The in vivo study of Beagle dogs revealed that the plasma concentration of JUC-C10 reached the maximum concentration and effec- tive blood level earlier than the original API after oral administration, which suggested that JUC-C10 exhibited a more rapid absorption profile and could thus achieve a rapid onset of action.
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    Journal Title
    Inorganic Chemistry Communications
    Volume
    39
    DOI
    https://doi.org/10.1016/j.inoche.2013.11.007
    Copyright Statement
    © 2014 Elsevier Inc. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Inorganic chemistry
    Inorganic chemistry not elsewhere classified
    Other chemical sciences
    Publication URI
    http://hdl.handle.net/10072/61153
    Collection
    • Journal articles

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