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  • The clinical role of glutamine supplementation in patients with multiple trauma: a narrative review

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    Author(s)
    Al Balushi, R.
    Cohen, J.
    Banks, M.
    Paratz, Jennifer D.
    Griffith University Author(s)
    Paratz, Jenny D.
    Year published
    2013
    Metadata
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    Abstract
    Glutamine is considered an essential amino acid during stress and critical illness. Parenteral glutamine supplementation in critically ill patients has been shown to improve survival rate and minimise infectious complications, costs and hospital length-of-stay. However, glutamine supplementation in patients receiving enteral nutrition and the best method of administration are still controversial. The purpose of this article is to provide a narrative review of the current evidence and trials of enteral and parenteral glutamine supplementation in multiple trauma patients. A search in PubMed and EMBASE was conducted and relevant ...
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    Glutamine is considered an essential amino acid during stress and critical illness. Parenteral glutamine supplementation in critically ill patients has been shown to improve survival rate and minimise infectious complications, costs and hospital length-of-stay. However, glutamine supplementation in patients receiving enteral nutrition and the best method of administration are still controversial. The purpose of this article is to provide a narrative review of the current evidence and trials of enteral and parenteral glutamine supplementation in multiple trauma patients. A search in PubMed and EMBASE was conducted and relevant papers that investigated the effect of enteral or parenteral glutamine supplementation in patients with multiple trauma were reviewed. Although recent nutritional guidelines recommend that glutamine supplementation should be considered in these patients, further well-designed trials are required to provide a confirmed conclusion. Due to the inconclusive results of enteral glutamine supplementation trials in patients receiving enteral nutrition, future trials should focus on intravenous glutamine supplementation in patients requiring enteral nutrition and on major clinical outcome measures (e.g. mortality rate, infectious complications).
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    Journal Title
    Anaesthesia and Intensive Care
    Volume
    41
    Issue
    1
    Publisher URI
    http://www.aaic.net.au/Document/?D=20120164
    Copyright Statement
    © 2013 Australian Society of Anaesthetists. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Anaesthesiology
    Intensive Care
    Physiotherapy
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/61331
    Collection
    • Journal articles

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