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dc.contributor.authorM. Kim, Susy
dc.contributor.authorKumar, Vimlesh
dc.contributor.authorLin, Yong-Qi
dc.contributor.authorKarunanithi, Shanker
dc.contributor.authorRamaswami, Mani
dc.date.accessioned2017-05-03T13:14:35Z
dc.date.available2017-05-03T13:14:35Z
dc.date.issued2009
dc.date.modified2014-07-21T05:08:19Z
dc.identifier.issn0027-8424
dc.identifier.doi10.1073/pnas.0806064106
dc.identifier.urihttp://hdl.handle.net/10072/61382
dc.description.abstractIn all nervous systems, short-term enhancement of transmitter release is achieved by increasing the weights of unitary synapses; in contrast, long-term enhancement, which requires nuclear gene expression, is generally thought to be mediated by the addition of new synaptic vesicle release sites. In Drosophila motor neurons, induction of AP-1, a heterodimer of Fos and Jun, induces cAMP- and CREB-dependent forms of presynaptic enhancement. Light and electron microscopic studies indicate that this synaptic enhancement is caused by increasing the weight of unitary synapses and not through the insertion of additional release sites. Electrophysiological and optical measurements of vesicle dynamics demonstrate that enhanced neurotransmitter release is accompanied by an increase in the actively cycling synaptic vesicle pool at the expense of the reserve pool. Finally, the observation that AP-1 mediated enhancement eliminates tetanus-induced forms of presynaptic potentiation suggests: (i) that reserve-pool mobilization is required for tetanus-induced short-term synaptic plasticity; and (ii) that long-term synaptic plasticity may, in some instances, be accomplished by stable recruitment of mechanisms that normally underlie short-term synaptic change.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNational Academy of Sciences
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom4000
dc.relation.ispartofpageto4005
dc.relation.ispartofissue10
dc.relation.ispartofjournalNational Academy of Sciences. Proceedings (PNAS)
dc.relation.ispartofvolume106
dc.rights.retentionY
dc.subject.fieldofresearchPure Mathematics not elsewhere classified
dc.subject.fieldofresearchcode010199
dc.titleFos and Jun potentiate individual release sites and mobilize the reserve synaptic-vesicle pool at the Drosophila larval motor synapse
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorKarunanithi, Shanker


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