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dc.contributor.authorTuppin, Michael Patrick
dc.contributor.authorParatz, Jennifer D.
dc.contributor.authorChang, Angela T.
dc.contributor.authorSeale, Helen E.
dc.contributor.authorWalsh, James R.
dc.contributor.authorKermeeen, Fiona D.
dc.contributor.authorMcNeil, Keith D.
dc.contributor.authorHopkins, Peter M.
dc.date.accessioned2017-05-03T13:14:43Z
dc.date.available2017-05-03T13:14:43Z
dc.date.issued2008
dc.date.modified2014-07-21T05:08:24Z
dc.identifier.issn1557-3117
dc.identifier.doi10.1016/j.healun.2008.03.017
dc.identifier.urihttp://hdl.handle.net/10072/61386
dc.description.abstractBackground The 6-minute walk distance (6MWD) is a widely used clinical indicator of exercise capacity. Although used as part of the assessment process in determining a candidate's suitability for lung transplantation (LT), the literature describing the impact of the 6MWD in predicting survival on LT waiting lists is limited. This study aimed to determine the hazard function associated with the 6MWD, and its utility relative to other prognostic variables. Methods A retrospective chart review was conducted on 163 patients who were listed for single or double LT, and either survived to transplant or died while on the waiting list. A Cox regression for survival analysis, stratified by diagnostic group, was conducted utilizing the 6MWD, demographic variables and measures of cardiopulmonary function. Results The 6MWD proved to be the only significant covariate in the Cox regression for survival analysis (p < 0.001), with all other variables eliminated as non-significant. Furthermore, there was a protective effect for each unit increase in the 6MWD [Exp (B) = 0.994, 95% confidence interval 0.990 to 0.997]. Conclusions This research demonstrates that the 6MWD is useful for stratifying patients on the LT waiting list by identifying those patients with a significantly higher risk of mortality.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom729
dc.relation.ispartofpageto734
dc.relation.ispartofjournalThe Journal of Heart and Lung Transplantation
dc.relation.ispartofvolume27
dc.rights.retentionY
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchCardiovascular medicine and haematology not elsewhere classified
dc.subject.fieldofresearchcode3201
dc.subject.fieldofresearchcode320199
dc.titlePredictive Utility of the 6-Minute Walk Distance on Survival in Patients Awaiting Lung Transplantation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorParatz, Jenny D.


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