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  • Antiplasmodial Triterpenoids from the Fruits of Neem, Azadirachta indica

    Author(s)
    Chianese, G
    Yerbanga, SR
    Lucantoni, L
    Habluetzel, A
    Basilico, N
    Taramelli, D
    Fattorusso, E
    Taglialatela-Scafati, O
    Griffith University Author(s)
    Lucantoni, Leonardo
    Year published
    2010
    Metadata
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    Abstract
    Eight known and two new triterpenoid derivatives, neemfruitins A (9) and B (10), have been isolated from the fruits of neem, Azadirachta indica, a traditional antimalarial plant used by Asian and African populations. In vitro antiplasmodial tests evidenced a significant activity of the known gedunin and azadirone and the new neemfruitin A and provided useful information about the structure−antimalarial activity relationships in the limonoid class.Eight known and two new triterpenoid derivatives, neemfruitins A (9) and B (10), have been isolated from the fruits of neem, Azadirachta indica, a traditional antimalarial plant used by Asian and African populations. In vitro antiplasmodial tests evidenced a significant activity of the known gedunin and azadirone and the new neemfruitin A and provided useful information about the structure−antimalarial activity relationships in the limonoid class.
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    Journal Title
    Journal of Natural Products
    Volume
    73
    DOI
    https://doi.org/10.1021/np100325q
    Copyright Statement
    Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
    Subject
    Biological Sciences not elsewhere classified
    Chemical Sciences
    Biological Sciences
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/61411
    Collection
    • Journal articles

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