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dc.contributor.authorDivers, Jasmin
dc.contributor.authorD. Palmer, Nicholette
dc.contributor.authorLu, Lingyi
dc.contributor.authorRegister, Thomas C.
dc.contributor.authorCarr, J. Jeffrey
dc.contributor.authorHicks, Pamela J.
dc.contributor.authorCaresse Hightower, R.
dc.contributor.authorCarrie Smith, S.
dc.contributor.authorXu, Jianzhao
dc.contributor.authorCox, Amanda J.
dc.contributor.authorA. Hruska, Keith
dc.contributor.authorBowden, Donald W.
dc.contributor.authorE. Lewis, Cora
dc.contributor.authorHeiss, Gerardo
dc.contributor.authorA. Province, Michael
dc.contributor.authorB. Borecki, Ingrid
dc.contributor.authorF. Kerr, Kathleen
dc.contributor.authorIda Chen, Y.
dc.contributor.authorPalmas, Walter
dc.contributor.authorI. Rotter, Jerome
dc.contributor.authorL. Wassel, Christina
dc.contributor.authorBertoni, Alain G.
dc.contributor.authorHerrington, David M.
dc.contributor.authorE. Wagenknecht, Lynne
dc.contributor.authorLangefeld, Carl D.
dc.contributor.authorFreedman, Barry I.
dc.date.accessioned2017-06-19T01:30:33Z
dc.date.available2017-06-19T01:30:33Z
dc.date.issued2013
dc.date.modified2014-07-22T04:27:33Z
dc.identifier.issn1942-325X
dc.identifier.doi10.1161/CIRCGENETICS.112.964114
dc.identifier.urihttp://hdl.handle.net/10072/61481
dc.description.abstractBackground-The presence and severity of coronary artery calcified plaque (CAC) differs markedly between individuals of African and European descent, suggesting that admixture mapping may be informative for identifying genetic variants associated with subclinical cardiovascular disease. Methods and Results-Admixture mapping of CAC was performed in 1040 unrelated African Americans with type 2 diabetes mellitus from the African American-Diabetes Heart Study, Multi-Ethnic Study of Atherosclerosis and Family Heart Study using the Illumina custom ancestry informative marker panel. All cohorts obtained computed tomography scanning of the coronary arteries using identical protocols. For each ancestry informative marker, the probability of inheriting 0, 1, and 2 copies of a European-derived allele was determined. Linkage analysis was performed by testing for association between each ancestry informative marker using these probabilities and CAC, accounting for global ancestry, age, sex, and study. Markers on 1p32.3 in the GLIS1 gene (rs6663966, logarithm of odds [LOD]=3.7), 1q32.1 near CHIT1 (rs7530895, LOD=3.1), 4q21.2 near PRKG2 (rs1212373, LOD=3.0), and 11q25 in the OPCML gene (rs6590705, LOD=3.4) had statistically significant LOD scores, whereas markers on 8q22.2 (rs6994682, LOD=2.7), 9p21.2 (rs439314, LOD=2.7), and 13p32.1 (rs7492028, LOD=2.8) manifested suggestive evidence of linkage. These regions were uniformly characterized by higher levels of European ancestry associating with higher levels or odds of CAC. Findings were replicated in 1350 African Americans without diabetes mellitus and 2497 diabetic European Americans from Multi-Ethnic Study of Atherosclerosis and the Diabetes Heart Study. Conclusions-Fine mapping these regions will likely identify novel genetic variants that contribute to CAC and clarify racial differences in susceptibility to subclinical cardiovascular disease.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherLippincott Williams and Wilkins
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom97
dc.relation.ispartofpageto105
dc.relation.ispartofjournalCirculation: Cardiovascular Genetics
dc.relation.ispartofvolume6
dc.rights.retentionY
dc.subject.fieldofresearchCardiorespiratory Medicine and Haematology not elsewhere classified
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchMedical Biotechnology
dc.subject.fieldofresearchCardiorespiratory Medicine and Haematology
dc.subject.fieldofresearchcode110299
dc.subject.fieldofresearchcode0604
dc.subject.fieldofresearchcode1004
dc.subject.fieldofresearchcode1102
dc.titleAdmixture Mapping of Coronary Artery Calcified Plaque in African Americans With Type 2 Diabetes Mellitus
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorCox, Amanda J.


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