Show simple item record

dc.contributor.authorAshton, KJ
dc.contributor.authorWeinstein, SR
dc.contributor.authorMaguire, DJ
dc.contributor.authorGriffiths, LR
dc.date.accessioned2017-05-03T12:15:46Z
dc.date.available2017-05-03T12:15:46Z
dc.date.issued2003
dc.date.modified2009-11-18T05:32:33Z
dc.identifier.issn0003-987X
dc.identifier.urihttp://hdl.handle.net/10072/6149
dc.description.abstractObjective To identify chromosomal copy numbers of frequent genetic aberrations within squamous cell carcinomas (SCCs) and solar keratoses (SKs), and provide further evidence to support or challenge current dogma concerning the relationship between these lesions. Design Retrospective analysis of genetic aberrations in DNA from SK and SCC biopsy specimens by comparative genomic hybridization. Setting University-based research laboratory in Queensland, Australia. Patients Twenty-two biopsy specimens from patients with diagnosed SKs (n = 7), cutaneous SCCs (n = 10), or adjoining lesions (n = 5). Main Outcome Measure Identification of frequent genetic aberrations both specific to SK and SCC and shared by these lesions to investigate their clonal relationship. Results Shared genomic imbalances were identified in SK and SCC. Frequent gains were located at chromosome arms 3q, 17q, 4p, 14q, Xq, 5p, 9q, 8q, 17p, and 20q, whereas shared regional losses were observed at 9p, 3p, 13q, 17p, 11p, 8q, and 18p. Significant loss of 18q was observed only in SCC lesions. Conclusions Our results demonstrate that numerous chromosomal aberrations are shared by the 2 lesions, suggesting a clonal relationship between SK and SCC. Additionally, the genomic loss of 18q may be a significant event in SK progression to SCC. Finally, the type and frequency of aberrations suggests a common mode of tumorigenesis in SCC-derived tumors.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Medical Association
dc.publisher.placeUnited States
dc.publisher.urihttp://www.ncbi.nlm.nih.gov/pubmed/12873882
dc.relation.ispartofpagefrom876
dc.relation.ispartofpageto882
dc.relation.ispartofissue7
dc.relation.ispartofjournalArchives of Dermatology
dc.relation.ispartofvolume139
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.titleChromosomal Aberrations in Squamous Cell Carcinoma and Solar Keratoses Revealed by Comparative Genomic Hybridization
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.date.issued2003
gro.hasfulltextNo Full Text
gro.griffith.authorMaguire, David J.
gro.griffith.authorGriffiths, Lyn
gro.griffith.authorWeinstein, Stephen R.
gro.griffith.authorAshton, Kevin J.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record