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dc.contributor.authorSmith, Roberten_US
dc.contributor.authorLea, Rodneyen_US
dc.contributor.authorCurran, Joanneen_US
dc.contributor.authorWeinstein, Stephenen_US
dc.contributor.authorGriffiths, Lynen_US
dc.contributor.editorBruce AJ Ponderen_US
dc.date.accessioned2017-05-03T12:15:46Z
dc.date.available2017-05-03T12:15:46Z
dc.date.issued2003en_US
dc.date.modified2009-11-18T05:31:12Z
dc.identifier.issn14655411en_US
dc.identifier.doi10.1186/bcr556en_AU
dc.identifier.urihttp://hdl.handle.net/10072/6151
dc.description.abstractBackground Previous studies in our laboratory have shown associations of specific nuclear receptor gene variants with sporadic breast cancer. In order to investigate these findings further, we conducted the present study to determine whether expression levels of the progesterone and glucocorticoid nuclear receptor genes vary in different breast cancer grades. Methods RNA was extracted from paraffin-embedded archival breast tumour tissue and converted into cDNA. Sample cDNA underwent PCR using labelled primers to enable quantitation of mRNA expression. Expression data were normalized against the 18S ribosomal gene multiplex and analyzed using analysis of variance. Results Analysis of variance indicated a variable level of expression of both genes with regard to breast cancer grade (P = 0.00033 for glucocorticoid receptor and P = 0.023 for progesterone receptor). Conclusion Statistical analysis indicated that expression of the progesterone nuclear receptor is elevated in late grade breast cancer tissue.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent53230 bytes
dc.format.extent19122 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherBioMed Centralen_US
dc.publisher.placeUnited Kingdomen_US
dc.publisher.urihttp://breast-cancer-research.com/en_AU
dc.relation.ispartofpagefromR9en_US
dc.relation.ispartofpagetoR12en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalBreast Cancer Researchen_US
dc.relation.ispartofvolume5en_US
dc.subject.fieldofresearchcode270201en_US
dc.titleExpression of glucocorticoid and progesterone nuclear receptor genes in archival breast cancer tissueen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
dcterms.licensehttp://creativecommons.org/licenses/by/2.0en_US
gro.facultyGriffith Health, School of Medicineen_US
gro.rights.copyrightCopyright 2003 Smith et al., licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_AU
gro.date.issued2003
gro.hasfulltextFull Text


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