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dc.contributor.authorWinzer, Brooke M.
dc.contributor.authorC. Whiteman, David
dc.contributor.authorM. Reeves, Marina
dc.contributor.authorParatz, Jennifer D.
dc.date.accessioned2017-05-03T13:14:39Z
dc.date.available2017-05-03T13:14:39Z
dc.date.issued2011
dc.date.modified2014-07-22T04:30:24Z
dc.identifier.issn09575243
dc.identifier.doi10.1007/s10552-011-9761-4
dc.identifier.urihttp://hdl.handle.net/10072/61562
dc.description.abstractBackground Physically active individuals have lower rates of many cancers and improved cancer outcomes. Controlled exercise trials measuring putative biomarkers of cancer risk are being conducted to further understand the role of exercise in cancer etiology and progression. We aimed to systematically review the effect of exercise on various biomarkers. Methods A comprehensive search strategy identified 353 publications from January 1980 to August 2010. We included those clinical trials of exercise measuring biomarkers following minimum 4-week intervention among cancer survivors or people with one or more cancer risk factors. Two reviewers abstracted data and assessed quality independently. Effect sizes and 95% confidence intervals were estimated. Results Four primary prevention and five tertiary prevention trials were included. Exercise had a small to moderate effect on improving concentrations of several blood biomarkers implicated in breast and colon cancer pathways including insulin, leptin, estrogens, and apoptosis regulation. In breast cancer survivors, exercise had a small to moderate effect on improving some biomarkers associated with prognosis including various insulin-like growth factor axis proteins, insulin, and inflammation; and a large effect on enhancing immune function. Conclusion Data are few, but there is some evidence to support the role of exercise in modulating various cancer pathways.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer Netherlands
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom811
dc.relation.ispartofpageto826
dc.relation.ispartofjournalCancer Causes & Control:
dc.relation.ispartofvolume22
dc.rights.retentionY
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchOncology and carcinogenesis not elsewhere classified
dc.subject.fieldofresearchcode3211
dc.subject.fieldofresearchcode321199
dc.titlePhysical activity and cancer prevention: a systematic review of clinical trials
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorParatz, Jenny D.


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