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dc.contributor.authorCox, Amanda J.
dc.contributor.authorHsu, Fang-Chi
dc.contributor.authorCarr, J. Jeffrey
dc.contributor.authorFreedman, Barry I.
dc.contributor.authorBowden, Donald W.
dc.date.accessioned2017-06-19T01:30:31Z
dc.date.available2017-06-19T01:30:31Z
dc.date.issued2013
dc.date.modified2014-07-28T06:54:01Z
dc.identifier.issn14752840
dc.identifier.doi10.1186/1475-2840-12-68
dc.identifier.urihttp://hdl.handle.net/10072/61596
dc.description.abstractBackground Risk stratification in individuals with type 2 diabetes (T2D) remains an important priority in the management of associated morbidity and mortality, including from cardiovascular disease (CVD). The current investigation examined whether estimated glomerular filtration rate (eGFR) and urine albumin:creatinine ratio (UACR) were independent predictors of CVD-mortality in European Americans (EAs) with T2D after accounting for subclinical CVD. Methods The family-based Diabetes Heart Study (DHS) cohort (n=1,220) had baseline measures of serum creatinine, eGFR, UACR and coronary artery calcified plaque (CAC) assessed by non-contrast computed tomography scan. Cox proportional hazards regression was performed to determine risk for all-cause mortality and CVD-mortality associated with indices of kidney disease after accounting for traditional CVD risk factors and CAC as a measure of subclinical CVD. Results Participants were followed for 8.2Ხ6 years (meanᓄ) during which time 247 (20.9%) were deceased, 107 (9.1%) from CVD. Univariate analyses revealed positive associations between serum creatinine (HR:1.56; 95% CI:1.37-1.80; p<0.0001) and UACR (1.59; 1.43-1.77; p>0.0001) and negative associations between serum albumin (0.74; 0.65-0.84; p<0.0001) and eGFR (0.66; 0.58-0.76; p<0.0001) with all-cause mortality. Associations remained significant after adjustment for traditional CVD risk factors, as well as for CAC. Similar trends were noted when predicting risk for CVD-mortality. Conclusions The DHS reveals that kidney function and albuminuria are independent risk factors for all-cause mortality and CVD-mortality in EAs with T2D, even after accounting for CAC. Keywords: Coronary artery calcified plaque; Mortality; Albuminuria; Type 2 diabetes; Risk prediction
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent161607 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto7
dc.relation.ispartofissue68
dc.relation.ispartofjournalCardiovascular Diabetology
dc.relation.ispartofvolume12
dc.rights.retentionY
dc.subject.fieldofresearchCardiorespiratory Medicine and Haematology not elsewhere classified
dc.subject.fieldofresearchCardiorespiratory Medicine and Haematology
dc.subject.fieldofresearchcode110299
dc.subject.fieldofresearchcode1102
dc.titleGlomerular filtration rate and albuminuria predict mortality independently from coronary artery calcified plaque in the Diabetes Heart Study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/2.0
gro.description.notepublicPage numbers are not for citation purposes. Instead, this article has the unique article number of 68.
gro.rights.copyright© 2013 Cox et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.date.issued2013
gro.hasfulltextFull Text
gro.griffith.authorCox, Amanda J.


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