Evolution of Equine Influenza Virus in Vaccinated Horses
Author(s)
Murcia, Pablo R.
Baillie, Gregory J.
Conrad Stack, J.
Jervis, Carley
Elton, Debra
Mumford, Jennifer A.
Daly, Janet
Kellam, Paul
Grenfell, Bryan T.
Holmes, Edward C.
Wood, James L. N.
Griffith University Author(s)
Year published
2013
Metadata
Show full item recordAbstract
Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity were similar to those in naﶥ horses, intrahost bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites.Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity were similar to those in naﶥ horses, intrahost bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites.
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Journal Title
Journal of Virology
Volume
87
Issue
8
Subject
Agricultural and Veterinary Sciences not elsewhere classified
Biological Sciences
Agricultural and Veterinary Sciences
Medical and Health Sciences