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  • Evolution of Equine Influenza Virus in Vaccinated Horses

    Author(s)
    Murcia, Pablo R.
    Baillie, Gregory J.
    Conrad Stack, J.
    Jervis, Carley
    Elton, Debra
    Mumford, Jennifer A.
    Daly, Janet
    Kellam, Paul
    Grenfell, Bryan T.
    Holmes, Edward C.
    Wood, James L. N.
    Griffith University Author(s)
    Baillie, Greg
    Year published
    2013
    Metadata
    Show full item record
    Abstract
    Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity were similar to those in naﶥ horses, intrahost bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites.Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity were similar to those in naﶥ horses, intrahost bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites.
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    Journal Title
    Journal of Virology
    Volume
    87
    Issue
    8
    DOI
    https://doi.org/10.1128/JVI.03379-12
    Subject
    Agricultural and Veterinary Sciences not elsewhere classified
    Biological Sciences
    Agricultural and Veterinary Sciences
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/61609
    Collection
    • Journal articles

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