Show simple item record

dc.contributor.authorFenning, A
dc.contributor.authorHarrison, G
dc.contributor.authorDwyer, D
dc.contributor.authorRose'Meyer, R
dc.contributor.authorBrown, L
dc.date.accessioned2017-05-03T11:37:01Z
dc.date.available2017-05-03T11:37:01Z
dc.date.issued2003
dc.date.modified2010-07-30T07:19:59Z
dc.identifier.issn0300-8177
dc.identifier.doi10.1023/A:1025465412329
dc.identifier.urihttp://hdl.handle.net/10072/6192
dc.description.abstractEndurance exercise is widely assumed to improve cardiac function in humans. This project has determined cardiac function following endurance exercise for 6 (n = 30) or 12 (n = 25) weeks in male Wistar rats (8 weeks old). The exercise protocol was 30 min/day at 0.8 km/h for 5 days/week with an endurance test on the 6th day by running at 1.2 km/h until exhaustion. Exercise endurance increased by 318% after 6 weeks and 609% after 12 weeks. Heart weight/kg body weight increased by 10.2% after 6 weeks and 24.1% after 12 weeks. Echocardiography after 12 weeks showed increases in left ventricular internal diameter in diastole (6.39 ᠰ.32 to 7.90 ᠰ.17 mm), systolic volume (49 ᠷ to 83 ᠱ1 嬩 and cardiac output (75 ᠳ to 107 ᠸ ml/min) but not left wall thickness in diastole (1.74 ᠰ.07 to 1.80 ᠰ.06 mm). Isolated Langendorff hearts from trained rats displayed decreased left ventricular myocardial stiffness (22 ᠱ.1 to 19.1 ᠰ.3) and reduced purine efflux during pacing-induced workload increases. 31P-NMR spectroscopy in isolated hearts from trained rats showed decreased PCr and PCr/ATP ratios with increased creatine, AMP and ADP concentrations. Thus, this endurance exercise protocol resulted in physiological hypertrophy while maintaining or improving cardiac function. (Mol Cell Biochem 251: 51-59, 2003)
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_AU
dc.publisherKluwer Academic / Plenum Publishers
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom51
dc.relation.ispartofpageto59
dc.relation.ispartofjournalMolecular and Cellular Biochemistry: an international journal for chemical biology in health and disease
dc.relation.ispartofvolume251
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchcode0601
dc.titleCardiac adaptation to endurance exercise in rats
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2003
gro.hasfulltextNo Full Text
gro.griffith.authorHarrison, Glenn J.
gro.griffith.authorDwyer, Dan
gro.griffith.authorRose'Meyer, Roselyn B.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record