© 2014 Wiley Periodicals, Inc.. This is the accepted version of the following article: LEAP: Highly accurate prediction of protein loop conformations by integrating coarse-grained sampling and optimized energy scores with all-atom refinement of backbone and side chains, Journal of Computational Chemistry, Volume 35, Issue 4, pages 335–341, 5 February 2014, which has been published in final form at http://dx.doi.org/10.1002/jcc.23509