Predictive Value of Prospective Memory for Remission in First-Episode Schizophrenia
Author(s)
Zhou, Fu-Chun
Xiang, Yu-Tao
Wang, Chuan-Yue
Dickerson, Faith
Kreyenbuhl, Julie
Ungvari, Gabor S
Au, Raymond WC
Zhou, Jing-Jing
Zhou, Yan
Shum, David
Man, David
Lai, Kelly YC
Tang, Wai-Kwong
Yu, Xin
Chiu, Helen FK
Griffith University Author(s)
Year published
2014
Metadata
Show full item recordAbstract
Purpose The study examined the rate of remission in individuals experiencing a first episode of schizophrenia (FES) in China and explored predictors of remission in the acute phase of the illness. Design and Methods Fifty-five FES patients were randomly treated with risperidone, olanzapine, or aripiprazole at therapeutic doses for 8 weeks, and their clinical profiles and cognition were assessed using standardized assessment instruments at entry and the end of the study. Findings Of the 55 patients, 30 (54.5%) remitted by the end of the 8-week study. In univariate analyses, shorter duration of untreated psychosis, higher ...
View more >Purpose The study examined the rate of remission in individuals experiencing a first episode of schizophrenia (FES) in China and explored predictors of remission in the acute phase of the illness. Design and Methods Fifty-five FES patients were randomly treated with risperidone, olanzapine, or aripiprazole at therapeutic doses for 8 weeks, and their clinical profiles and cognition were assessed using standardized assessment instruments at entry and the end of the study. Findings Of the 55 patients, 30 (54.5%) remitted by the end of the 8-week study. In univariate analyses, shorter duration of untreated psychosis, higher scores on both the time-based prospective memory (TBPM) and event-based prospective memory tasks and the Hopkins Verbal Learning Test-revised, and less severe negative symptoms were significantly associated with remission. In stepwise multiple logistic regression analyses, only higher scores on the TBPM significantly predicted remission. Individuals having higher scores reflecting better TBPM at baseline were more likely to achieve remission after 8 weeks of optimized antipsychotic treatment. Practice Implications TPBM may be useful in helping clinicians identify those FES patients most likely to achieve a favorable treatment response.
View less >
View more >Purpose The study examined the rate of remission in individuals experiencing a first episode of schizophrenia (FES) in China and explored predictors of remission in the acute phase of the illness. Design and Methods Fifty-five FES patients were randomly treated with risperidone, olanzapine, or aripiprazole at therapeutic doses for 8 weeks, and their clinical profiles and cognition were assessed using standardized assessment instruments at entry and the end of the study. Findings Of the 55 patients, 30 (54.5%) remitted by the end of the 8-week study. In univariate analyses, shorter duration of untreated psychosis, higher scores on both the time-based prospective memory (TBPM) and event-based prospective memory tasks and the Hopkins Verbal Learning Test-revised, and less severe negative symptoms were significantly associated with remission. In stepwise multiple logistic regression analyses, only higher scores on the TBPM significantly predicted remission. Individuals having higher scores reflecting better TBPM at baseline were more likely to achieve remission after 8 weeks of optimized antipsychotic treatment. Practice Implications TPBM may be useful in helping clinicians identify those FES patients most likely to achieve a favorable treatment response.
View less >
Journal Title
Perspectives in Psychiatric Care
Volume
50
Issue
2
Subject
Nursing
Nursing not elsewhere classified