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dc.contributor.authorTomasetti, Marco
dc.contributor.authorNeuzil, Jiri
dc.contributor.authorDong, Lanfeng
dc.date.accessioned2017-05-03T15:36:05Z
dc.date.available2017-05-03T15:36:05Z
dc.date.issued2014
dc.date.modified2014-08-08T04:00:37Z
dc.identifier.issn0304-4165
dc.identifier.doi10.1016/j.bbagen.2013.09.002
dc.identifier.urihttp://hdl.handle.net/10072/62002
dc.description.abstractBackground Mitochondria, essential to the cell homeostasis maintenance, are central to the intrinsic apoptotic pathway and their dysfunction is associated with multiple diseases. Recent research documents that microRNAs (miRNAs) regulate important signalling pathways in mitochondria, and many of these miRNAs are deregulated in various diseases including cancers. Scope of review In this review, we summarise the role of miRNAs in the regulation of the mitochondrial bioenergetics/function, and discuss the role of miRNAs modulating the various metabolic pathways resulting in tumour suppression and their possible therapeutic applications. Major conclusions MiRNAs have recently emerged as key regulators of metabolism and can affect mitochondria by modulating mitochondrial proteins coded by nuclear genes. They were also found in mitochondria. Reprogramming of the energy metabolism has been postulated as a major feature of cancer. Modulation of miRNAs levels may provide a new therapeutic approach for the treatment of mitochondria-related pathologies, including neoplastic diseases. General significance The elucidation of the role of miRNAs in the regulation of mitochondrial activity/bioenergetics will deepen our understanding of the molecular aspects of various aspects of cell biology associated with the genesis and progression of neoplastic diseases. Eventually, this knowledge may promote the development of innovative pharmacological interventions. This article is part of a Special Issue entitled Frontiers of Mitochondrial Research.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1441
dc.relation.ispartofpageto1453
dc.relation.ispartofissue4
dc.relation.ispartofjournalBiochimica et Biophysica Acta. General Subjects
dc.relation.ispartofvolume1840
dc.rights.retentionY
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1115
dc.titleMicroRNAs as regulators of mitochondrial function: Role in cancer suppression
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorNeuzil, Jiri
gro.griffith.authorDong, Lan-feng


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