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  • An efficient microfluidic sorter: Implementation of double meandering micro striplines for magnetic particles switching

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    Author(s)
    Kong, Tian Fook
    Shin E, Huan
    Sugiarto, Hendrik Santoso
    Liew, Hwi Fen
    Wang, Xinghua
    Lew, Wen Siang
    Nguyen, Nam-Trung
    Chen, Yong
    Griffith University Author(s)
    Nguyen, Nam-Trung
    Year published
    2011
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    Abstract
    The ability to trap, manipulate, and separate magnetic beads has become one of the key requirements in realizing an integrated magnetic lab-on-chip biosensing system. In this article, we present the design and fabrication of an integrated magneto-fluidic device for sorting magnetic particles with a sorting efficiency of up to 95%. The actuation and manipulation of magnetic beads are realized using microfabricated square meandering current-carrying micro striplines. The current is alternated between two neighboring micro striplines to switch the magnetic beads to either one of the two outlets. We performed a series of parametric ...
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    The ability to trap, manipulate, and separate magnetic beads has become one of the key requirements in realizing an integrated magnetic lab-on-chip biosensing system. In this article, we present the design and fabrication of an integrated magneto-fluidic device for sorting magnetic particles with a sorting efficiency of up to 95%. The actuation and manipulation of magnetic beads are realized using microfabricated square meandering current-carrying micro striplines. The current is alternated between two neighboring micro striplines to switch the magnetic beads to either one of the two outlets. We performed a series of parametric study to investigate the effect of applied current, flow rate, and switching frequency on the sorting efficiency. Experimental results reveal that the sorting efficiency is proportional to the square of current applied to the stripline, and decreases with increasing buffer flow rate and switching frequency. Such phenomena agree well with our theoretical analysis and simulation result. The fastest switching rate, which is limited by the microchannel geometry and bead velocity, is 2 Hz.
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    Journal Title
    Microfluidics and Nanofluidics
    Volume
    10
    Issue
    5
    DOI
    https://doi.org/10.1007/s10404-010-0735-8
    Copyright Statement
    © 2011 Springer Berlin Heidelberg. This is an electronic version of an article published in Microfluidics and Nanofluidics, Volume 10, Issue 5, pp 1069-1078, 2011. Microfluidics and Nanofluidics is available online at: http://link.springer.com/ with the open URL of your article.
    Subject
    Interdisciplinary Engineering not elsewhere classified
    Mechanical Engineering
    Interdisciplinary Engineering
    Nanotechnology
    Publication URI
    http://hdl.handle.net/10072/62195
    Collection
    • Journal articles

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