dc.contributor.author | Power, Peter M | |
dc.contributor.author | Seib, Kate L | |
dc.contributor.author | Jennings, Michael P | |
dc.date.accessioned | 2012-11-02 | |
dc.date.accessioned | 2014-08-15T01:50:52Z | |
dc.date.accessioned | 2017-03-02T00:24:30Z | |
dc.date.available | 2017-03-02T00:24:30Z | |
dc.date.issued | 2006 | |
dc.date.modified | 2014-08-15T01:50:52Z | |
dc.identifier.issn | 0006-291X | |
dc.identifier.doi | 10.1016/j.bbrc.2006.06.182 | |
dc.identifier.uri | http://hdl.handle.net/10072/62261 | |
dc.description.abstract | Pili (type IV fimbriae) of Neisseria meningitidis are glycosylated by the addition of O-linked sugars. Recent work has shown that PglF, a protein with homology to O-antigen 'flippases', is required for the biosynthesis of the pilin-linked glycan and suggests pilin glycosylation occurs in a manner analogous to the wzy-dependent addition of O-antigen to the core-LPS. O-Antigen ligases are crucial in this pathway for the transfer of undecraprenol-linked sugars to the LPS-core in Gram-negative bacteria. An O-antigen ligase homologue, pglL, was identified in N. meningitidis. PglL mutants showed no change in LPS phenotypes but did show loss of pilin glycosylation, confirming PglL is essential for pilin O-linked glycosylation in N. meningitidis. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | United Kingdom | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 904 | |
dc.relation.ispartofpageto | 908 | |
dc.relation.ispartofissue | 4 | |
dc.relation.ispartofjournal | Biochemical and Biophysical Research Communications | |
dc.relation.ispartofvolume | 347 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry | |
dc.subject.fieldofresearch | Biochemistry and cell biology | |
dc.subject.fieldofresearch | Bacteriology | |
dc.subject.fieldofresearch | Medical biochemistry and metabolomics | |
dc.subject.fieldofresearchcode | 3404 | |
dc.subject.fieldofresearchcode | 3101 | |
dc.subject.fieldofresearchcode | 310701 | |
dc.subject.fieldofresearchcode | 3205 | |
dc.title | Pilin glycosylation in Neisseria meningitidis occurs by a similar pathway to wzy-dependent O-antigen biosynthesis in Escherichia coli. | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | c1x | |
gro.faculty | Faculty of Science, Environment, Engineering and Technology | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Seib, Kate | |
gro.griffith.author | Jennings, Michael P. | |