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  • A Sco homologue plays a role in defence against oxidative stress in pathogenic Neisseria.

    Author(s)
    Seib, KL
    Jennings, MP
    McEwan, AG
    Griffith University Author(s)
    Seib, Kate
    Jennings, Michael P.
    Year published
    2003
    Metadata
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    Abstract
    Sco proteins are found in mitochondria and in a variety of oxidase positive bacteria. Although Sco is required for the formation of the CuA centre in a cytochrome oxidase of the aa3 type, it was observed that oxidases with a CuA centre are not present in many bacteria that contain a Sco homologue. Two bacteria of this type are the pathogens Neisseria meningitidis and Neisseria gonorrhoeae. The sco genes of N. gonorrhoeae strain 1291 and N. meningitidis strain MC58 were cloned, inactivated by inserting a kanamycin resistance cassette and used to make knockout mutants by allelic exchange. Both N. gonorrhoeae and N. meningitidis ...
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    Sco proteins are found in mitochondria and in a variety of oxidase positive bacteria. Although Sco is required for the formation of the CuA centre in a cytochrome oxidase of the aa3 type, it was observed that oxidases with a CuA centre are not present in many bacteria that contain a Sco homologue. Two bacteria of this type are the pathogens Neisseria meningitidis and Neisseria gonorrhoeae. The sco genes of N. gonorrhoeae strain 1291 and N. meningitidis strain MC58 were cloned, inactivated by inserting a kanamycin resistance cassette and used to make knockout mutants by allelic exchange. Both N. gonorrhoeae and N. meningitidis sco mutants were highly sensitive to oxidative killing by paraquat, indicating that Sco is involved in protection against oxidative stress in these bacteria.
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    Journal Title
    FEBS Letters
    Volume
    546
    Issue
    2-3
    DOI
    https://doi.org/10.1016/S0014-5793(03)00632-X
    Subject
    Medicinal and biomolecular chemistry
    Biochemistry and cell biology
    Evolutionary biology
    Bacteriology
    Publication URI
    http://hdl.handle.net/10072/62262
    Collection
    • Journal articles

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