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dc.contributor.authorSeib, KL
dc.contributor.authorJennings, MP
dc.contributor.authorMcEwan, AG
dc.date.accessioned2012-11-02
dc.date.accessioned2014-08-15T01:50:53Z
dc.date.accessioned2017-03-02T00:24:31Z
dc.date.available2017-03-02T00:24:31Z
dc.date.issued2003
dc.date.modified2014-08-15T01:50:53Z
dc.identifier.issn0014-5793
dc.identifier.doi10.1016/S0014-5793(03)00632-X
dc.identifier.urihttp://hdl.handle.net/10072/62262
dc.description.abstractSco proteins are found in mitochondria and in a variety of oxidase positive bacteria. Although Sco is required for the formation of the CuA centre in a cytochrome oxidase of the aa3 type, it was observed that oxidases with a CuA centre are not present in many bacteria that contain a Sco homologue. Two bacteria of this type are the pathogens Neisseria meningitidis and Neisseria gonorrhoeae. The sco genes of N. gonorrhoeae strain 1291 and N. meningitidis strain MC58 were cloned, inactivated by inserting a kanamycin resistance cassette and used to make knockout mutants by allelic exchange. Both N. gonorrhoeae and N. meningitidis sco mutants were highly sensitive to oxidative killing by paraquat, indicating that Sco is involved in protection against oxidative stress in these bacteria.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofpagefrom411
dc.relation.ispartofpageto415
dc.relation.ispartofissue2-3
dc.relation.ispartofjournalFEBS Letters
dc.relation.ispartofvolume546
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchEvolutionary biology
dc.subject.fieldofresearchBacteriology
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3104
dc.subject.fieldofresearchcode310701
dc.titleA Sco homologue plays a role in defence against oxidative stress in pathogenic Neisseria.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codec1x
gro.facultyFaculty of Science, Environment, Engineering and Technology
gro.hasfulltextNo Full Text
gro.griffith.authorSeib, Kate
gro.griffith.authorJennings, Michael P.


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