Azurin of pathogenic Neisseria spp. is involved in defense against hydrogen peroxide and survival within cervical epithelial cells.

View/ Open
File version
Version of Record (VoR)
Author(s)
Wu, HJ
Seib, KL
Edwards, JL
Apicella, MA
McEwan, AG
Jennings, MP
Year published
2005
Metadata
Show full item recordAbstract
Laz, a lipid-modified azurin of the human pathogens Neisseria gonorrhoeae and Neisseria meningitidis, is involved in defense against oxidative stress and copper toxicity; laz mutant strains are hypersensitive to hydrogen peroxide and copper. The N. gonorrhoeae laz mutant also has decreased survival in an ex vivo primary human ectocervical epithelial assay.Laz, a lipid-modified azurin of the human pathogens Neisseria gonorrhoeae and Neisseria meningitidis, is involved in defense against oxidative stress and copper toxicity; laz mutant strains are hypersensitive to hydrogen peroxide and copper. The N. gonorrhoeae laz mutant also has decreased survival in an ex vivo primary human ectocervical epithelial assay.
View less >
View less >
Journal Title
Infection and Immunity
Volume
73
Issue
12
Copyright Statement
© 2005 American Society for Microbiology. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Subject
Biological sciences
Bacteriology
Agricultural, veterinary and food sciences
Biomedical and clinical sciences
Microbiology
Immunology
Medical microbiology