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  • Azurin of pathogenic Neisseria spp. is involved in defense against hydrogen peroxide and survival within cervical epithelial cells.

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    Version of Record (VoR)
    Author(s)
    Wu, HJ
    Seib, KL
    Edwards, JL
    Apicella, MA
    McEwan, AG
    Jennings, MP
    Griffith University Author(s)
    Seib, Kate
    Jennings, Michael P.
    Year published
    2005
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    Abstract
    Laz, a lipid-modified azurin of the human pathogens Neisseria gonorrhoeae and Neisseria meningitidis, is involved in defense against oxidative stress and copper toxicity; laz mutant strains are hypersensitive to hydrogen peroxide and copper. The N. gonorrhoeae laz mutant also has decreased survival in an ex vivo primary human ectocervical epithelial assay.Laz, a lipid-modified azurin of the human pathogens Neisseria gonorrhoeae and Neisseria meningitidis, is involved in defense against oxidative stress and copper toxicity; laz mutant strains are hypersensitive to hydrogen peroxide and copper. The N. gonorrhoeae laz mutant also has decreased survival in an ex vivo primary human ectocervical epithelial assay.
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    Journal Title
    Infection and Immunity
    Volume
    73
    Issue
    12
    DOI
    https://doi.org/10.1128/IAI.73.12.8444-8448.2005
    Copyright Statement
    © 2005 American Society for Microbiology. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Biological sciences
    Bacteriology
    Agricultural, veterinary and food sciences
    Biomedical and clinical sciences
    Microbiology
    Immunology
    Medical microbiology
    Publication URI
    http://hdl.handle.net/10072/62276
    Collection
    • Journal articles

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