dc.contributor.author | Murphy, KJ | |
dc.contributor.author | Chronopoulos, AK | |
dc.contributor.author | Singh, I | |
dc.contributor.author | Francis, MA | |
dc.contributor.author | Moriarty, H | |
dc.contributor.author | Pike, MJ | |
dc.contributor.author | Turner, AH | |
dc.contributor.author | Mann, NJ | |
dc.contributor.author | Sinclair, AJ | |
dc.date.accessioned | 2013-04-05 | |
dc.date.accessioned | 2014-08-15T01:54:08Z | |
dc.date.accessioned | 2017-03-02T00:24:44Z | |
dc.date.available | 2017-03-02T00:24:44Z | |
dc.date.issued | 2003 | |
dc.date.modified | 2014-08-15T01:54:08Z | |
dc.identifier.issn | 0002-9165 | |
dc.identifier.uri | http://hdl.handle.net/10072/62289 | |
dc.description.abstract | Background: Flavonoids may be partly responsible for some health benefits, including antiinflammatory action and a decreased tendency for the blood to clot. An acute dose of flavanols and oligomeric procyanidins from cocoa powder inhibits platelet activation and function over 6 h in humans.
Objective: This study sought to evaluate whether 28 d of supplementation with cocoa flavanols and related procyanidin oligomers would modulate human platelet reactivity and primary hemostasis and reduce oxidative markers in vivo.
Design: Thirty-two healthy subjects were assigned to consume active (234 mg cocoa flavanols and procyanidins/d) or placebo (≤ 6 mg cocoa flavanols and procyanidins/d) tablets in a blinded parallel-designed study. Platelet function was determined by measuring platelet aggregation, ATP release, and expression of activation-dependent platelet antigens by using flow cytometry. Plasma was analyzed for oxidation markers and antioxidant status.
Results: Plasma concentrations of epicatechin and catechin in the active group increased by 81% and 28%, respectively, during the intervention period. The active group had significantly lower P selectin expression and significantly lower ADP-induced aggregation and collagen-induced aggregation than did the placebo group. Plasma ascorbic acid concentrations were significantly higher in the active than in the placebo group (P < 0.05), whereas plasma oxidation markers and antioxidant status did not change in either group.
Conclusions: Cocoa flavanol and procyanidin supplementation for 28 d significantly increased plasma epicatechin and catechin concentrations and significantly decreased platelet function. These data support the results of acute studies that used higher doses of cocoa flavanols and procyanidins. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Society of Clinical Nutrition | |
dc.publisher.place | Bethesda, MD, USA | |
dc.publisher.uri | http://ajcn.nutrition.org/content/77/6/1466.short | |
dc.relation.ispartofpagefrom | 1466 | |
dc.relation.ispartofpageto | 1473 | |
dc.relation.ispartofissue | 6 | |
dc.relation.ispartofjournal | American Journal of Clinical Nutrition | |
dc.relation.ispartofvolume | 77 | |
dc.subject.fieldofresearch | Other biological sciences not elsewhere classified | |
dc.subject.fieldofresearch | Engineering | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearchcode | 319999 | |
dc.subject.fieldofresearchcode | 40 | |
dc.subject.fieldofresearchcode | 32 | |
dc.title | Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | c1x | |
gro.faculty | Faculty of Science, Environment, Engineering and Technology | |
gro.rights.copyright | Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author for more information. | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Singh, Indu | |