Show simple item record

dc.contributor.authorMurphy, KJ
dc.contributor.authorChronopoulos, AK
dc.contributor.authorSingh, I
dc.contributor.authorFrancis, MA
dc.contributor.authorMoriarty, H
dc.contributor.authorPike, MJ
dc.contributor.authorTurner, AH
dc.contributor.authorMann, NJ
dc.contributor.authorSinclair, AJ
dc.date.accessioned2013-04-05
dc.date.accessioned2014-08-15T01:54:08Z
dc.date.accessioned2017-03-02T00:24:44Z
dc.date.available2017-03-02T00:24:44Z
dc.date.issued2003
dc.date.modified2014-08-15T01:54:08Z
dc.identifier.issn0002-9165
dc.identifier.urihttp://hdl.handle.net/10072/62289
dc.description.abstractBackground: Flavonoids may be partly responsible for some health benefits, including antiinflammatory action and a decreased tendency for the blood to clot. An acute dose of flavanols and oligomeric procyanidins from cocoa powder inhibits platelet activation and function over 6 h in humans. Objective: This study sought to evaluate whether 28 d of supplementation with cocoa flavanols and related procyanidin oligomers would modulate human platelet reactivity and primary hemostasis and reduce oxidative markers in vivo. Design: Thirty-two healthy subjects were assigned to consume active (234 mg cocoa flavanols and procyanidins/d) or placebo (≤ 6 mg cocoa flavanols and procyanidins/d) tablets in a blinded parallel-designed study. Platelet function was determined by measuring platelet aggregation, ATP release, and expression of activation-dependent platelet antigens by using flow cytometry. Plasma was analyzed for oxidation markers and antioxidant status. Results: Plasma concentrations of epicatechin and catechin in the active group increased by 81% and 28%, respectively, during the intervention period. The active group had significantly lower P selectin expression and significantly lower ADP-induced aggregation and collagen-induced aggregation than did the placebo group. Plasma ascorbic acid concentrations were significantly higher in the active than in the placebo group (P < 0.05), whereas plasma oxidation markers and antioxidant status did not change in either group. Conclusions: Cocoa flavanol and procyanidin supplementation for 28 d significantly increased plasma epicatechin and catechin concentrations and significantly decreased platelet function. These data support the results of acute studies that used higher doses of cocoa flavanols and procyanidins.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Society of Clinical Nutrition
dc.publisher.placeBethesda, MD, USA
dc.publisher.urihttp://ajcn.nutrition.org/content/77/6/1466.short
dc.relation.ispartofpagefrom1466
dc.relation.ispartofpageto1473
dc.relation.ispartofissue6
dc.relation.ispartofjournalAmerican Journal of Clinical Nutrition
dc.relation.ispartofvolume77
dc.subject.fieldofresearchOther biological sciences not elsewhere classified
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode319999
dc.subject.fieldofresearchcode40
dc.subject.fieldofresearchcode32
dc.titleDietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codec1x
gro.facultyFaculty of Science, Environment, Engineering and Technology
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author for more information.
gro.hasfulltextNo Full Text
gro.griffith.authorSingh, Indu


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record